HERC4
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Official Full Name
hect domain and RLD 4 -
Overview
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)). -
Synonyms
HERC4;hect domain and RLD 4;probable E3 ubiquitin-protein ligase HERC4;DKFZP564G092;KIAA1593;HECT domain and RCC1 like domain containing protein 4;HECT domain and RCC1-like domain-containing protein 4;HERC 4;HERC4_HUMAN;Probable E3 ubiquitin protein ligase HERC4;OTTHUMP00000019692;OTTHUMP00000019693;OTTHUMP00000217539;OTTHUMP00000217540
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- GST
- His
- His&Fc&Avi
Involved Pathway
HERC4 involved in several pathways and played different roles in them. We selected most pathways HERC4 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CDC26,UBE4B,UBE2NA,UBOX5,MGRN1,UBE2D3,UBE2E1,RCHY1,CDH1-A,UBE2D4 |
Protein Function
HERC4 has several biochemical functions, for example, ligase activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC4 itself. We selected most functions HERC4 had, and list some proteins which have the same functions with HERC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | RING1,MARCH9,NAPRT,RNF4,PCXA,ZSWIM2,UFL1,DTX1,PRP19,RNF168 |
| ubiquitin protein ligase activity | RNF111,HECW2,PDZRN3B,ASB4,UBE2T,RNF217,HECTD2,SIAH1,HERC2,RNF14 |
Interacting Protein
HERC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC4.
HSP90AB1
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References
- Zhou, H; Shi, R; et al. The expression and clinical significance of HERC4 in breast cancer. CANCER CELL INTERNATIONAL 13:-(2013).
- Imami, K; Bhavsar, AP; et al. Global Impact of Salmonella Pathogenicity Island 2-secreted Effectors on the Host Phosphoproteome. MOLECULAR & CELLULAR PROTEOMICS 12:1632-1643(2013).
