HDAC7
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Official Full Name
histone deacetylase 7 -
Overview
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
HDAC7;histone deacetylase 7;HD7A;HDAC7A;HD7;histone deacetylase 7A
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Insect Cells
- HEK293
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
HDAC7 involved in several pathways and played different roles in them. We selected most pathways HDAC7 participated on our site, such as Alcoholism,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | UBE3A,TBPL2,MAPK3,TBP,H2BFWT,CCNE1,DLG1,TRAF5,SYK,PKM |
| Alcoholism | BRAF,NTRK2,SHC1,H2AFB1,NPY,HIST1H2AJ,PPP1CB,GRB2,HIST1H2AD,KRAS |
Protein Function
HDAC7 has several biochemical functions, for example, 14-3-3 protein binding,NAD-dependent histone deacetylase activity (H3-K14 specific),activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC7 itself. We selected most functions HDAC7 had, and list some proteins which have the same functions with HDAC7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 14-3-3 protein binding | IRS2,PPP1R12A,ARRB2,PRKCZ,DDIT4,AKT1,TSC2,KIF13B,KCNH1,AANAT |
| chromatin binding | OST4,HMGB3A,SIX1,SMC1A,CREB3L1,CBFA2T3,KLF6A,PCNA,RNF168,FLI1 |
| transcription factor binding | TWIST1,GATA4,TAF7L,PER1,ARNT,PITX2,JUNB,PPRC1,PPARG,HEY1 |
| protein kinase C binding | GNB2L1,DSP,HDAC5,PDLIM5,FEZ1,MARCKS,GRK5,SDC4,PARD3,TOP2A |
| protein kinase binding | ZFP36,FAM83E,KIF13B,GCET2,NGFRAP1,TRIB3,CCND1,NME2,FGR,HSP90AB1 |
| repressing transcription factor binding | KAT5,NOC2L,SRI,TLE4,DDX20,SKI,TBP,CTBP1,PRDM5,TCF3 |
| protein binding | UBE2K,HIST2H3C,LY6H,MAGI2,KEAP1,LGALS9C,TCTEX1D2,CRY1,UFL1,IGFBP3 |
| transcription corepressor activity | ATF5,SIRT1,TBL1XR1A,ZHX2,SAP18,ENO1,AJUBA,PFDN5,DAXX,NR2F2 |
| histone deacetylase activity | HDAC8,MTA2,HDAC10,HDAC6,SIRT1,HDAC1,HDAC5,HDAC4,NACC2,HDAC11 |
Interacting Protein
HDAC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC7.
Ywhae;Ncor2;Mef2a;Mef2c
HDAC7 Related Signal Pathway
Resources
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References
- Jin, ZX; Wei, W; et al. HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered beta-Catenin Switch. MOLECULAR ENDOCRINOLOGY 27:325-335(2013).
- Hu, N; Long, H; et al. Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 38:464-471(2009).
