HCFC1
-
Official Full Name
host cell factor C1 (VP16-accessory protein) -
Overview
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. -
Synonyms
HCFC1;host cell factor C1 (VP16-accessory protein);HFC1;host cell factor 1;CFF;HCF 1;HCF1;MGC70925;VCAF;HCF;C1 factor;VP16 accessory protein;HCF-1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HCFC1-13692H | Recombinant Human HCFC1, GST-tagged | E.coli | Human | GST | 1-350a.a. | |
| HCFC1-3753H | Recombinant Human HCFC1 protein, His-tagged | E.coli | Human | His | 1-350 aa | |
| HCFC1-29188TH | Recombinant Human HCFC1 | Wheat Germ | Human | Non | 87 amino acids |
|
| HCFC1-4617H | Recombinant Human HCFC1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| HCFC1-7514M | Recombinant Mouse HCFC1 Protein | Mammalian Cell | Mouse | His |
|
|
| HCFC1-3353H | Recombinant Human HCFC1 Protein (Asn52-His258), His tagged | E.coli | Human | His | Asn52-His258 |
|
| HCFC1-3505HF | Recombinant Full Length Human HCFC1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 428 amino acids |
|
| HCFC1-4079M | Recombinant Mouse HCFC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| HCFC1-4079M-B | Recombinant Mouse HCFC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| HCFC1-407H | Recombinant Human HCFC1 Protein, His-tagged | E.coli | Human | His | Asn52~His258 |
|
| Hcfc1-408M | Recombinant Mouse Hcfc1 Protein, His-tagged | E.coli | Mouse | His | Ser107~Thr332 |
|
Involved Pathway
HCFC1 involved in several pathways and played different roles in them. We selected most pathways HCFC1 participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCFC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | EEF1DA,OAS2,IFNA16,EIF2AK4,IFNA13,TP53,PER3,TAF13,Ifna15,SRSF7 |
Protein Function
HCFC1 has several biochemical functions, for example, chromatin binding,contributes_to histone acetyltransferase activity (H4-K16 specific),contributes_to histone acetyltransferase activity (H4-K5 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HCFC1 itself. We selected most functions HCFC1 had, and list some proteins which have the same functions with HCFC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to histone acetyltransferase activity (H4-K16 specific) | KANSL3,OGT,KAT8,KIAA1267,PHF20B,MCRS1,KANSL2 |
| protein binding | LPL,ARHGAP24,ASIC1,UACA,ZMAT3,VAMP1,RB1CC1,BFSP2,RRAGA,Cd79a |
| contributes_to histone acetyltransferase activity (H4-K5 specific) | KANSL3,PHF20B,KANSL2,KAT8,OGT,MCRS1,KIAA1267 |
| transcription coactivator activity | BRCA1,TFDP1A,JUPA,RARA,MED7,FHL5,CREBBP,RAP2C,TAF12,RB1 |
| transcription factor activity, sequence-specific DNA binding | ZFP110,TCF3A,SOX1,KCNA3,HOXB2A,SIX1,TBX5,ZFP35,PPARAB,ATF5A |
| contributes_to histone acetyltransferase activity (H4-K8 specific) | OGT,KAT8,MCRS1,PHF20B,KANSL2,KANSL3,KIAA1267 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | FOXH1,CDX1,POU4F1,SUB1,MIXL1,NFE2L2,NFKB1,SIX6,ZEB2,CUX1 |
| chromatin binding | SMARCA2,DLX2,LHX2,SMAD6,TMPOA,TCF7,UBTFL,MECP2,HMGB3,EOMES |
| identical protein binding | SHANK3,SEPHS1,GM5077,HCN4,TRAF6,PRNP,PARK7,RABAC1,CLPP,NUP153 |
Interacting Protein
HCFC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCFC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCFC1.
CREBZF;CREB3;OGT
Resources
Related Services
Related Products
References
- Mohan, GS; Ye, L; et al. Less Is More: Ebola Virus Surface Glycoprotein Expression Levels Regulate Virus Production and Infectivity. JOURNAL OF VIROLOGY 89:1205-1217(2015).
- Gehring, G; Rohrmann, K; et al. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 69:2123-2131(2014).
