HARS2
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Official Full Name
histidyl-tRNA synthetase 2, mitochondrial (putative) -
Overview
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. -
Synonyms
HARS2;histidyl-tRNA synthetase 2, mitochondrial (putative);HARSL, histidyl tRNA synthetase like;probable histidyl-tRNA synthetase, mitochondrial;HARSR;histidine tRNA ligase 2;mitochondrial (putative);HO3;Harsl;4631412B19Rik;AI593507;HARS 2;HARS related;HisRS;Histidine translase;Histidine tRNA ligase;Histidine tRNA ligase homolog;Histidine tRNA ligase like;Histidyl tRNA synthetase 2 mitochondrial;Histidyl tRNA synthetase like;Probable histidyl tRNA synthetase mitochondrial;HARS-related;histidine-tRNA ligase homolog;histidine tRNA ligase 2, mitochondrial (putative)
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- His&SUMO
Involved Pathway
HARS2 involved in several pathways and played different roles in them. We selected most pathways HARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | VARS2,FARS2,CARS,NARS,YARS,QARS,MARS,DARS,SARS2,AARS2 |
Protein Function
HARS2 has several biochemical functions, for example, ATP binding,histidine-tRNA ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HARS2 itself. We selected most functions HARS2 had, and list some proteins which have the same functions with HARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | ZCCHC8,MACF1,BTF3,TSNAX,EIF4B,FUBP1,USP10,PRPF38B,NUDT16L1,RBM28 |
| histidine-tRNA ligase activity | HARS |
| ATP binding | TTL,PRKAG2,PRKACG,NOL9,STK24A,ADCY1,ORC4,PAK6,KATNAL1,TLK1A |
| protein binding | DNASE1,CACYBP,ASL,TSKS,ETV4,LPL,PTPN11,SERPING1,SMARCAD1,PTGDR |
| protein homodimerization activity | PTPRE,EVLA,CBX1,APOA1BP,RAB11FIP2,ASGR1,PDE2A,ABCD2,ZBTB16,ADAM10 |
Interacting Protein
HARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HARS2.
AGTRAP;gag;BST2;ssrna_ug;AURKA;ORC1;ICT1;GTF2H5;VPS16
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References
- Badura-Stronka, M; Wawrocka, A; et al. Severe manifestation of Leber's hereditary optic neuropathy due to 11778G > A mtDNA mutation in a female with hypoestrogenism due to Perrault syndrome. MITOCHONDRION 13:831-834(2013).
- Jenkinson, EM; Rehman, AU; et al. Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease. AMERICAN JOURNAL OF HUMAN GENETICS 92:605-613(2013).
