HAP1
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Official Full Name
huntingtin-associated protein 1 -
Overview
Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified. -
Synonyms
HAP1;huntingtin-associated protein 1;HAP2;hHLP1;HIP5;HLP;neuroan 1;HAP-1;huntingtin-associated protein 2
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&GST
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HAP1-2789R | Recombinant Rat HAP1 Protein | Mammalian Cell | Rat | His |
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| HAP1-4573H | Recombinant Human HAP1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HAP1-499H | Recombinant Human HAP1 | Mammalian Cell | Human | His |
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| HAP1-1598H | Recombinant Human HAP1 protein, His & GST-tagged | E.coli | Human | His&GST | Pro160~Gln381 |
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| Hap1-1599M | Recombinant Mouse Hap1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Cys132~Glu328 |
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| Hap1-1600R | Recombinant Rat Hap1 protein, His & GST-tagged | E.coli | Rat | His&GST | Gln349~Arg584 |
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| HAP1-2443R | Recombinant Rat HAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HAP1-2443R-B | Recombinant Rat HAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HAP1-3095H | Recombinant Human HAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| HAP1-3095H-B | Recombinant Human HAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| HAP1-3354HF | Recombinant Full Length Human HAP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 671 amino acids |
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Involved Pathway
HAP1 involved in several pathways and played different roles in them. We selected most pathways HAP1 participated on our site, such as GABAergic synapse,Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | GPX1,NDUFA8,NDUFA6,SLC25A6,SP1,UQCRFS1,DNAH11,DCTN4,HDAC2,BAX |
| GABAergic synapse | GNG3,GLS,SLC6A13,PRKCG,GABBR2,SLC38A1,GABRB1,GPHN,GNG7,SLC38A2 |
Protein Function
HAP1 has several biochemical functions, for example, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAP1 itself. We selected most functions HAP1 had, and list some proteins which have the same functions with HAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase binding | PRDX3,BARD1,DLG1,HPCA,TAX1BP1,PARK2,PER1,STX1A,PFKFB1,SP100 |
Interacting Protein
HAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAP1.
AHI1;HMOX2;RPS10;TAF1D;C8orf33;ATXN3;PSMD11;RER1;MGEA5
Resources
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References
- Murray, GL; et al. The lipoprotein LipL32, an enigma of leptospiral biology. VETERINARY MICROBIOLOGY 162:305-314(2013).
- Islam, MN; Fujinaga, R; et al. CHARACTERIZATION OF THE "SPORADICALLY LURKING HAP1-IMMUNOREACTIVE (SLH) CELLS" IN THE HIPPOCAMPUS, WITH SPECIAL REFERENCE TO THE EXPRESSION OF STEROID RECEPTORS, GABA, AND PROGENITOR CELL MARKERS. NEUROSCIENCE 210:67-81(2012).
