H2AFY
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Official Full Name
H2A histone family, member Y -
Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
H2AFY;H2A histone family, member Y;core histone macro-H2A.1;macroH2A1.2;Core histone macro h2a.1;H2A histone family member Y;H2A.y;H2A/y;Histone macroH2A1;Histone macroH2A1.1;Histone macroH2A1.2;Macroh2a1;Medulloblastoma antigen MU MB 50.205;mH2a;mH2A1;histone H2A.y;OTTHUMP00000159413;OTTHUMP00000223174;OTTHUMP00000223175;OTTHUMP00000223176;medulloblastoma antigen MU-MB-50.205;H2AFJ;H2AF12M;MACROH2A1.1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His&T7
- HIS
- His
- GST
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
H2AFY involved in several pathways and played different roles in them. We selected most pathways H2AFY participated on our site, such as Alcoholism,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2AFY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | C3,HLA-DPB1,HIST3H2BB-PS,C1R,H2AFX,HLA-DPA1,ACTN3,HIST1H2BB,ELANE,FCGR4 |
| Alcoholism | HDAC1,HIST4H4,HDAC5,SLC18A1,MAOA,GRIN1,HIST1H2BB,HIST1H2AL,HIST2H4A,HIST2H2BE |
Protein Function
H2AFY has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H2AFY itself. We selected most functions H2AFY had, and list some proteins which have the same functions with H2AFY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | ESX1,RARA,POU3F4,ATF4B2,ALX4,GATA3,HOXD9,ZNF711,IKZF3,SKINT8 |
| protein binding | CTAG1B,SESTD1,RAB37,CP110,CREBBP,MAPK4,CKMT1,ABCD3,FGFRL1A,FDXR |
| protein kinase binding | APC,ACTA2,TPRKB,FOXO3,TRAF3,GOLGA2,ADIPOR1,EEF2,ERRFI1,KIF20A |
| rDNA binding | BEND3,GTF2H5 |
| DNA binding | FBXO21,POLDIP2,POLR3D,TCEANC,HIST1H4H,HIST1H2BP,DMRT3,SIM1,SIX6A,PARP1 |
| protein heterodimerization activity | HIST1H2AI,PHC2B,STX1A,MLXIPL,MTTP,HIST3H2A,HIST1H3F,CHRNA3,BIK,ZHX3 |
| double-stranded methylated DNA binding | MECP2,MBD1 |
| RNA polymerase II core promoter sequence-specific DNA binding | MTF1,TRP53,SOX3,H3F3A,NFIL3,NSD1,HEYL,GATA3,SMAD5,SUZ12 |
| transcription regulatory region DNA binding | SOX6,YY1,TAF7,FOXA1,DDIT3,ZNF567,SREBF1,GATA3,SMAD4,PAX2 |
Interacting Protein
H2AFY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2AFY here. Most of them are supplied by our site. Hope this information will be useful for your research of H2AFY.
ERICH2;ERBB2;ATF2;SRPK1;q7chd7_yerpe;yapB;PARP1;VCAM1;CD247;ATRX
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