GZMA
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Official Full Name
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) -
Overview
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008] -
Synonyms
GZMA;granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3);HFSP;CTLA3;granzyme A;HF;h factor;CTL tryptase;fragmentin-1;cytotoxic T-lymphocyte proteinase 1;Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3;Hanukah factor serine protease)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- NS0
- E.coli
- Wheat Germ
- Yeast
- P.pastoris
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- His&GST
- Flag
- His&B2M
Involved Pathway
GZMA involved in several pathways and played different roles in them. We selected most pathways GZMA participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GABBR1,SSTR2,ADORA1,GLRA1,CHRNB1,NPY8AR,TAAR12B,TAAR14L,ADCYAP1R1A,GALR3 |
Protein Function
GZMA has several biochemical functions, for example, protein binding,protein homodimerization activity,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMA itself. We selected most functions GZMA had, and list some proteins which have the same functions with GZMA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RAB9A,ARHGEF10,ZNF346,SART1,KDM4A,ITGB4,PTPN11,CAMK2A,RNF31,EIF2S1 |
| serine-type endopeptidase activity | ELANE,C1rb,PRSS38,PLG,F7,CTRC,KLK4,GZMF,CELA2B,MCPT8 |
| protein homodimerization activity | GSTM2,PAH,SRGAP2A,HPGDS,TOX3,KIAA1804,DMRT2A,HLCS,MITD1,CCL5 |
Interacting Protein
GZMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMA here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMA.
NDUFS3;purL;HSP90AA1;HSPA1A
Resources
Research Area
Serine Proteases and RegulatorsNatural Killer Cell (NK Cell)
Granzyme
Cytotoxic T Cells (CTLs)
gamma delta T Cells
Related Services
Related Products
References
- Kobayashi, M; Kaneko-Koike, C; et al. Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 173:411-418(2013).
- Li, JW; Ertel, A; et al. Postexposure Treatment with the Live-Attenuated Rabies Virus (RV) Vaccine TriGAS Triggers the Clearance of Wild-Type RV from the Central Nervous System (CNS) through the Rapid Induction of Genes Relevant to Adaptive Immunity in CNS Tissues. JOURNAL OF VIROLOGY 86:3200-3210(2012).
