GTF2A2
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Official Full Name
general transcription factor IIA, 2, 12kDa -
Overview
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II;(POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM;189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA;element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both;TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3;subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded;by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2;(DeJong et al., 1995 (PubMed 7724559)). -
Synonyms
GTF2A2;general transcription factor IIA, 2, 12kDa;general transcription factor IIA, 2 (12kD subunit);transcription initiation factor IIA subunit 2;HsT18745;TFIIA;TFIIAS;TFIIA-12;TFIIA-gamma;TFIIA p12 subunit;general transcription factor IIA subu
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Zebrafish
- Chicken
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- T7
- GST
- His&Fc&Avi
Involved Pathway
GTF2A2 involved in several pathways and played different roles in them. We selected most pathways GTF2A2 participated on our site, such as Basal transcription factors,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal transcription factors | TAF6,GTF2E1,TAF9B,GTF2B,GTF2H5,GTF2A1,TAF11,GTF2IRD1,TAF8,GTF2H3 |
| Viral carcinogenesis | PIK3CA,POLB,KAT2A,YWHAE,TBPL1,ATP6V0D1,TRADD,TP53,STAT5A,VDAC3 |
Protein Function
GTF2A2 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,TBP-class protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2A2 itself. We selected most functions GTF2A2 had, and list some proteins which have the same functions with GTF2A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | PVALB,PAH,SLC30A8,BMP4,TFRC,ECT2,FLT3LG,MAPK4,HNF1B,TG |
| protein heterodimerization activity | PANX1,MYO5A,ADD1,HMG20A,FZD9,TAF13,IL12B,MID2,RRAGC,HIST1H3H |
| transcription factor binding | NKX3,HDAC2,GATA3,MAPK1,NAAA,JUN,YWHAZ,HDAC5,TBX5,NCOA2 |
| protein binding | BOC,FADD,KIAA1143,SNRPC,FSHB,SART3,MRAP,LIN9,ELOVL6,DCP1A |
| RNA polymerase II repressing transcription factor binding | STAT3,SP1,TTC8,TBX5A,GSC,TBP,TCERG1,BBS10,MIXL1,BBS5 |
| TBP-class protein binding | PSMC3,PSMC1B,THRA,TAF1L,BRF1A,BRF1B,PSMC1A,PSMC2,PSMC5,TAF1 |
| transcription coactivator activity | SETD3,HINFP,BRDT,FHL5,BIRC2,CTBP2,PRRX1,Ankar,DDX17,GTF2F1 |
Interacting Protein
GTF2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2A2.
GTF2A1;TBP;GTF2A1;TBPL1
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