GSN
-
Official Full Name
gelsolin -
Overview
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GSN;gelsolin;ADF;AGEL;brevin;actin-depolymerizing factor
Recombinant Proteins
- Human
- Porcine
- Bovine
- Rat
- Cattle
- Mouse
- Chicken
- E.coli
- Porcine smooth muscle
- Bovine Plasma
- Porcine Plasma
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&T7
- His&GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
GSN involved in several pathways and played different roles in them. We selected most pathways GSN participated on our site, such as Fc gamma R-mediated phagocytosis,Regulation of actin cytoskeleton,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | TBPL2,ATF4,CCNE2,GRB2,HPN,HIST2H2BB,CCNE1,STAT5B,SNW1,HDAC2 |
| Regulation of Actin Cytoskeleton | SCINLB,MRAS,FGF22,F2,VAV2,CHRM2A,PAK7,PIP4K2A,MYL2,APC2 |
| Fc gamma R-mediated phagocytosis | WASF1,PIP5K1C,PIK3CG,PIP5K1A,FCGR3A,FCGR1A,SPHK2,PLA2G4A,WASF3,MARCKSL1 |
Protein Function
GSN has several biochemical functions, for example, actin binding,calcium ion binding,myosin II binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSN itself. We selected most functions GSN had, and list some proteins which have the same functions with GSN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| myosin II binding | GCSAM,GCET2,TRIOBP |
| calcium ion binding | EFCAB4B,EGF,CLSTN3,LTBP1,DGKG,PKD2L1,MYL9,CDH9,ENPP2,CCDC47 |
| protein binding | HPS4,SLC30A1,CEP44,SSX2,NRG4,TMEM41A,OSBPL3,HPCAL1,RAB10,ACTL6A |
| protein domain specific binding | MPP5,GABRR2,TNNI3,UNC13A,AKAP5,ERCC1,WHRN,TFDP1,TRIM11,MRPL17 |
| actin binding | VCL,TNNT2A,PAWR,WASH1,BCL7B,PHACTR3,MYO19,HIP1RB,WHAMM,TRPV4 |
Interacting Protein
GSN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSN here. Most of them are supplied by our site. Hope this information will be useful for your research of GSN.
ESR1;ARRB2;ARRB1;ESR2;act1;act-1;ACTA1;PPM1B;VDAC1;CASP4;TOM1L1;EGFR;q7arf1_yerpe
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References
- Wang, J; Yuan, XP; et al. GSN antibody pretreatment aggravates radiation-induced lung injury in mice. NUCLEAR SCIENCE AND TECHNIQUES 25:-(2014).
- Van Overbeke, W; Verhelle, A; et al. Chaperone Nanobodies Protect Gelsolin Against MT1-MMP Degradation and Alleviate Amyloid Burden in the Gelsolin Amyloidosis Mouse Model. MOLECULAR THERAPY 22:1768-1778(2014).
