GRK6
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Official Full Name
G protein-coupled receptor kinase 6 -
Overview
G protein-coupled receptor kinase 6 (GRK6) is a widely expressed member of the AGC Ser/Thr protein kinase family and is comprised of an AGC-kinase C-terminal domain, a protein kinase domain, and a RGS domain. GRK6, like other GRKs, possesses unique activity against activated G protein-coupled receptors, which serves to regulate activation-dependent desensitization of the GPCR active forms. Studies have shown a critical role for GRK6 in the regulation of lymphocyte CXCR4 activity. -
Synonyms
GRK6;G protein-coupled receptor kinase 6;GPRK6;FLJ32135
Recombinant Proteins
- Human
- Mouse
- E.coli
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His&GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GRK6 involved in several pathways and played different roles in them. We selected most pathways GRK6 participated on our site, such as Chemokine signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | PF4,CCL5,CXCL12,FOXO3,CXCL14,VAV1,CCL28,PIK3CG,WAS,ROCK1 |
| Endocytosis | PIP5K1C,ADRB3,HSP70,HLA-B,RAB5C,GRK5,PLD1,PARD6B,KIT,ARAP1 |
Protein Function
GRK6 has several biochemical functions, for example, ATP binding,G-protein coupled receptor kinase activity,beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK6 itself. We selected most functions GRK6 had, and list some proteins which have the same functions with GRK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-adrenergic receptor kinase activity | GRK5,ADRBK2,ADRBK1 |
| protein binding | COPG,CLOCKB,SH3BP4,BAK1,NEDD4L,DOCK2,BBS13,NME5,SILV,CHD |
| ATP binding | SBK1,OAS2,PANK1A,ITGB1BP3,TPX2,PIM1,ATP6V1A,TTL,ERCC6L,ACTR2 |
| G-protein coupled receptor kinase activity | GRK7,GRK7B,RLN1,GRK7A,ADRBK2,ADRBK1,GRK1A,GRK1,GRK5,GRK1B |
Interacting Protein
GRK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK6.
ROM1;HSP90AB1;PRSS23;ITGA5
GRK6 Related Signal Pathway
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References
- Zhou, Y; Huang, XD; et al. Decreased Expression and Role of GRK6 in Spinal Cord of Rats After Chronic Constriction Injury. NEUROCHEMICAL RESEARCH 38:2168-2179(2013).
- Nedi, T; White, PJ; et al. Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract. BIOCHEMICAL PHARMACOLOGY 81:123-133(2011).
