GRID2
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Official Full Name
glutamate receptor, ionotropic, delta 2 -
Overview
Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain.GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells.A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis.This strongly suggests a role for GRID2 in neuronal apoptotic death. -
Synonyms
GRID2;glutamate receptor, ionotropic, delta 2;glutamate receptor delta-2 subunit;GluR delta 2;GLUR D2;GLURD 2;GLURD2;Glutamate receptor delta 2 subunit;Glutamate receptor ionotropic delta 2;GRID 2;MGC117022;MGC117023;MGC117024;GluR-delta-2;OTTHUMP00000161600;OTTHUMP00000219270;gluR delta-2 subunit
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- His
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRID2-13530H | Recombinant Human GRID2, His-tagged | E.coli | Human | His | 20-358a.a. | |
| GRID2-1232Z | Recombinant Zebrafish GRID2 | Mammalian Cell | Zebrafish | His |
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| GRID2-2693R | Recombinant Rat GRID2 Protein | Mammalian Cell | Rat | His |
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| GRID2-7261M | Recombinant Mouse GRID2 Protein | Mammalian Cell | Mouse | His |
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| GRID2-2347R | Recombinant Rat GRID2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GRID2-2347R-B | Recombinant Rat GRID2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRID2-3925M | Recombinant Mouse GRID2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GRID2-3925M-B | Recombinant Mouse GRID2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GRID2-5335H | Recombinant Human GRID2 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GRID2 involved in several pathways and played different roles in them. We selected most pathways GRID2 participated on our site, such as Neuroactive ligand-receptor interaction,Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term depression | PRKG2,GNA12,CRH,GNAO1,PPP2CB,ITPR3,GNAQ,GNAS,KRAS,NRAS |
| Neuroactive ligand-receptor interaction | NPY4R,GRIN1A,MCHR2,MC1R,ADORA1,PRLR,GRM7,CNR1,PTGER2B,TAAR7D |
Protein Function
GRID2 has several biochemical functions, for example, PDZ domain binding,extracellular-glutamate-gated ion channel activity,glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRID2 itself. We selected most functions GRID2 had, and list some proteins which have the same functions with GRID2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ionotropic glutamate receptor activity | GRIA3B,GRIA4B,GRIA3A,GRIA2B,GRIN2BB,GRIA2,GRIA4,GRIN3B,GRIK5,GRIN1B |
| glutamate receptor activity | GRM2,GRM8,GRM3,GRM7,GRM6,GRIK5,GRM1,GRIA1,GRM5,GRM4 |
| scaffold protein binding | HOMER1,NLGN4X,KCNA5,KCNH2,NLGN1,P2RY1,DSP,PARK7,TREM1,KRT18 |
| extracellular-glutamate-gated ion channel activity | GRIN3A,GRIK5,GRIN2BB,GRIA2A,GRIA3B,GRIN1,GRIN2A,GRIN1A,GRIA4B,GRIK1 |
| PDZ domain binding | LRP2,CXADR,TBC1D10A,SLC26A6,ADRB1,PROSAPIP1,DLG3,DLG1,SDC2,SLC9A3R1 |
Interacting Protein
GRID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRID2.
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