GPX3
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Official Full Name
glutathione peroxidase 3 (plasma) -
Overview
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen;peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA;codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop;structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather;than as a stop signal. -
Synonyms
GPX3;glutathione peroxidase 3 (plasma);glutathione peroxidase 3;GPx-3;plasma glutathione peroxidase;extracellular glutathione peroxidase;GPx-P;GSHPx-3;GSHPx-P
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- Mammalian Cell
- HEK293
- E.coli
- HEK293F
- His
- Flag
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
GPX3 involved in several pathways and played different roles in them. We selected most pathways GPX3 participated on our site, such as Glutathione metabolism,Arachidonic acid metabolism,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GSTM5,GGT6,MGST1.1,GGCT,GSR,G6PD,GGT7,GSTP1,SMS,RRM2B |
| Thyroid hormone synthesis | CREB3L2,ATP1B2,TPO,Adcy4,GPX2,ATP1A4,HSPA5,GPX5,GNAQ,SLC5A5 |
| Arachidonic acid metabolism | PLA2G12A,PLA2G2F,CYP1A1,GGT1,CYP1B1,ALOX8,PTGES,CYP2C37,CYP2B6,CYP2N13 |
Protein Function
GPX3 has several biochemical functions, for example, glutathione peroxidase activity,protein binding,selenium binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX3 itself. We selected most functions GPX3 had, and list some proteins which have the same functions with GPX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| selenium binding | SELENBP2,DIO2,RPH3A,SEPP1,SEP15,SELT,DIO1,SELENBP1,GPX1 |
| protein binding | PDLIM3,CDYL2,CTDNEP1,MED17,CTDSP1,ARHGEF40,SEC23B,DOCK9,RBM25,cgr2b |
| transcription factor binding | GCM1,NAAA,FOXO4,PARD6A,NKX2-5,SP1,E2F4,FOS,JUNBA,MYOCD |
| glutathione peroxidase activity | GPX1,GPX6,MGST3,GPX4,GSTK1,GPX8,LTC4S,GSTZ1,GPX4B,GPX2 |
Interacting Protein
GPX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX3.
UBQLN1;q7cgd4_yerpe;ohrA;trmFO;fadH;livM2;ftsY
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References
- Anugu, S; Petersson-Wolfe, CS; et al. Effect of vitamin E on the immune system of ewes during late pregnancy and lactation. SMALL RUMINANT RESEARCH 111:83-89(2013).
- Lee, HJ; Do, JH; et al. Immunohistochemical evidence for the over-expression of Glutathione peroxidase 3 in clear cell type ovarian adenocarcinoma. MEDICAL ONCOLOGY 28:S522-S527(2011).
