GPR143

  • Official Full Name

    G protein-coupled receptor 143

  • Overview

    This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.

  • Synonyms

    GPR143;G protein-coupled receptor 143;OA1, ocular albinism 1 (Nettleship Falls);G-protein coupled receptor 143;ocular albinism 1 (Nettleship Falls);ALBINISM OCULAR TYPE I;G protein coupled receptor 143;GP143_HUMAN;MOA1;NETTLESHIP FALLS TYPE OCULAR ALBINISM;Ocular albinism type 1 protein;Ocular albinism type 1 protein homolog;Ocular albinism1 Nettleship Falls type;OA1;NYS6

Recombinant Proteins

  • Zebrafish
  • Chicken
  • Mouse
  • Human
  • Mus musculus
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GPR143-11078Z Recombinant Zebrafish GPR143 Mammalian Cell Zebrafish His
GPR143-5107C Recombinant Chicken GPR143 Mammalian Cell Chicken His
GPR143-7148M Recombinant Mouse GPR143 Protein Mammalian Cell Mouse His
GPR143-739HCL Recombinant Human GPR143 cell lysate Human Non
GPR143-3853M Recombinant Mouse GPR143 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GPR143-3853M-B Recombinant Mouse GPR143 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GPR143-5188H Recombinant Human GPR143 Protein Wheat Germ Human Non
GPR143-5189H Recombinant Human GPR143 Protein, GST-tagged Wheat Germ Human GST
GPR143-5639HF Recombinant Full Length Human GPR143 Protein In Vitro Cell Free System Human Full L. 693 amino acids
GPR143-5640HF Recombinant Full Length Human GPR143 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 424 amino acids
RFL26150HF Recombinant Full Length Human G-Protein Coupled Receptor 143(Gpr143) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-404)
RFL35466MF Recombinant Full Length Mouse G-Protein Coupled Receptor 143(Gpr143) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-405)

    Involved Pathway

    GPR143 involved in several pathways and played different roles in them. We selected most pathways GPR143 participated on our site, such as GPCRs, Other, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR143 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    GPCRs, Other GPR88,MRGPRH,OR10A5,GPR176,GPR18,VMN1R148,VN1R1,GPR162,S1PR1,CELSR2

    Protein Function

    GPR143 has several biochemical functions, for example, G-protein coupled receptor activity,L-DOPA binding,L-DOPA receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR143 itself. We selected most functions GPR143 had, and list some proteins which have the same functions with GPR143. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity OR51E2,TAS2R109,TAAR7F,PARAPINOPSINB,FFAR2,DRD4-RS,AVPR2L,LPAR1,OLFR998,OR10H1
    protein binding ARHGAP17,ATF6,HMGB4,FBP2,RNF183,PARP4,SV2B,UBE2IB,NAPA,IFITM3
    dopamine binding DRD1A,DRD2B,DRD1,DRD3,ADRB2,TH,DRD2A,DRD2L,SLC6A3,DRD4
    tyrosine binding YARS2,ORA1

    Interacting Protein

    GPR143 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR143 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR143.

    MLANA

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