GPR132
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Official Full Name
G protein-coupled receptor 132 -
Overview
This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression. -
Synonyms
GPR132;G protein-coupled receptor 132;probable G-protein coupled receptor 132;G2 accumulation;G2A;G2 accumulation protein;G protein-coupled receptor G2A;MGC99642
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- His
- Non
- His&Fc&Avi
- GST
- N-His-GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPR132-7139M | Recombinant Mouse GPR132 Protein | Mammalian Cell | Mouse | His |
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| GPR132-183H | Recombinant Human GPR132 Full Length Transmembrane protein(Nanodisc) | HEK293 | Human | Non | Full L. |
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| GPR132-3848M | Recombinant Mouse GPR132 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| GPR132-3848M-B | Recombinant Mouse GPR132 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GPR132-5181H | Recombinant Human GPR132 Protein | Wheat Germ | Human | Non |
|
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| GPR132-5182H | Recombinant Human GPR132 Protein, GST-tagged | Wheat Germ | Human | GST | 281-380 a.a. |
|
| GPR132-5621HF | Recombinant Full Length Human GPR132 Protein | In Vitro Cell Free System | Human | Full L. 221 amino acids |
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| GPR132-8542H | Recombinant Human GPR132 protein(311-380aa), His-GST-tagged | E.coli | Human | N-His-GST | 311-380aa |
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| RFL36621HF | Recombinant Full Length Human Probable G-Protein Coupled Receptor 132(Gpr132) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-380) |
|
Involved Pathway
GPR132 involved in several pathways and played different roles in them. We selected most pathways GPR132 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR132 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-odorant GPCRs | CELSR1,EMR4,BAI2,O3far1,OPN3,CELSR3,GPR15,RRH |
| GPCR downstream signaling | RAMP1,OPN4B,LPAR5A,ANXA1,PROK1,OR52J3,TAS2R3,RXFP2B,TAC1,SOUL4 |
| Signal Transduction | KAL1A,SST,SKILB,ANXA1C,OPN4A,RHOT2,UTS2D,HCAR1-2,ADCYAP1B,TNKS2 |
| G alpha (q) signalling events | QRFP,TAC1,NMS,GPR65,TRPC7,EDN3,NPSR1,FPR-RS3,ARHGEF25,DGKB |
| GPCRs, Other | VMN1R46,RRH,GPR55,VMN1R43,VMN1R52,SSTR2,GPR183,VMN1R41,GPR116,VN1R1 |
| Class A/1 (Rhodopsin-like receptors) | RLN3,RHOL,NPFFR2,EDNRB,PROK1,UTS2,CNR1,CX3CR1,OXGR1A.3,CXCL11.8 |
| Gastrin-CREB signalling pathway via PKC and MAPK | DGKG,ARHGEF25,ABHD12,NMBB,LPAR1,FPR-RS6,ANXA1B,PROKR2,LTB4R,NMBA |
| GPCR ligand binding | PROK1,PTGDR2,EDN3,CNR1,FZD10,EMR3,EDNRAB,GPR18,OPN4B,ADM |
Protein Function
GPR132 has several biochemical functions, for example, G-protein coupled receptor activity,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR132 itself. We selected most functions GPR132 had, and list some proteins which have the same functions with GPR132. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GPR88,MRGPRG,NPFFR1L3,TAAR12J,GPR4,GPR157,OLFR998,NPY8BR,CXCR4A,RHO |
| signal transducer activity | PPP1R12A,CD24,GNG12,ADRA1BB,UNC13B,PLCB3,V1RA8,OLFR11,V2RH7,TAAR11 |
Interacting Protein
GPR132 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR132 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR132.
Resources
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References
- Yin, J; Yu, FSX; et al. ERK1/2 Mediate Wounding- and G-protein-Coupled Receptor Ligands-Induced EGFR Activation via Regulating ADAM17 and HB-EGF Shedding. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 50:132-139(2009).
- Cook, LB; Zhu, CC; et al. Thyrotropin-releasing hormone receptor processing: Role of ubiquitination and proteasomal degradation. MOLECULAR ENDOCRINOLOGY 17:1777-1791(2003).
- Mace, G; Jaume, M; et al. Identification of mu-opioid receptor epitopes recognized by agonistic IgG. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 280:1142-1147(2001).
- Chandrasekar, B; Mummidi, S; et al. Fractalkine (CX3CL1) stimulated by nuclear factor kappa B (NF-kappa B)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. BIOCHEMICAL JOURNAL 373:547-558(2003).
