GNPTG
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Official Full Name
N-acetylglucosamine-1-phosphate transferase, gamma subunit -
Overview
This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma. -
Synonyms
GNPTG;N-acetylglucosamine-1-phosphate transferase, gamma subunit;C16orf27, chromosome 16 open reading frame 27 , GNPTAG, N acetylglucosamine 1 phosphotransferase, gamma subunit;N-acetylglucosamine-1-phosphotransferase subunit gamma;c316G12.3;CAB56184;GlcNAc phosphotransferase gamma subunit;GlcNAc-1-phosphotransferase subunit gamma;GNPTAG;LP2537;N-acetylglucosamine-1-phosphate transferase gamma subunit;RJD9;UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma;C16orf27
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNPTG-13379H | Recombinant Human GNPTG, His-tagged | E.coli | Human | His | 5-304a.a. | |
| GNPTG-291Z | Recombinant Zebrafish GNPTG | Mammalian Cells | Zebrafish | His |
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| GNPTG-4952C | Recombinant Chicken GNPTG | Mammalian Cells | Chicken | His |
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| GNPTG-7054M | Recombinant Mouse GNPTG Protein | Mammalian Cells | Mouse | His |
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| GNPTG-5840HCL | Recombinant Human GNPTG 293 Cell Lysate | HEK293 | Human | Non |
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| Gnptg-3266M | Recombinant Mouse Gnptg Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| GNPTG-3786M | Recombinant Mouse GNPTG Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GNPTG-3786M-B | Recombinant Mouse GNPTG Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GNPTG-5095H | Recombinant Human GNPTG Protein, GST-tagged | Wheat Germ | Human | GST |
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| GNPTG-5153H | Recombinant Human GNPTG Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| GNPTG-5406HF | Recombinant Full Length Human GNPTG Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 19-304 amino acids |
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Involved Pathway
GNPTG involved in several pathways and played different roles in them. We selected most pathways GNPTG participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNPTG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | AP1S2,AP1M1,NAGA,GBA,HEXA,CTSLA,GALCB,DNASE2B,AP1S3B,LAPTM4A |
Protein Function
GNPTG has several biochemical functions, for example, UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNPTG itself. We selected most functions GNPTG had, and list some proteins which have the same functions with GNPTG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | Flt3l,MID2,SLC51A,RRAGA,RPS19,PITX2,CRYM,DGCR8,BNIP3,MYOM3 |
| UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | GNPTAB |
Interacting Protein
GNPTG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNPTG here. Most of them are supplied by our site. Hope this information will be useful for your research of GNPTG.
SRPK1;phnI;kefB;UPF1;ANAPC15;Cdc23;Anapc2;Cdc16;Cdc26
Resources
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References
- Chen, H; Xu, JQ; et al. Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population. BMC GENETICS 16:-(2015).
- Idol, RA; Wozniak, DF; et al. Neurologic Abnormalities in Mouse Models of the Lysosomal Storage Disorders Mucolipidosis II and Mucolipidosis III gamma. PLOS ONE 9:-(2014).
