GNPDA2
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Official Full Name
glucosamine-6-phosphate deaminase 2 -
Overview
The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting;D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be;associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on;chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. -
Synonyms
GNPDA2;glucosamine-6-phosphate deaminase 2;glucosamine-6-phosphate isomerase 2;glucosamine 6 phosphate isomerase;SB52;GlcN6P deaminase 2;Glucosamine 6 phosphate deaminase 2;Glucosamine 6 phosphate isomerase 2;Glucosamine 6 phosphate isomerase SB52;Glucosamine-6-phosphate isomerase SB52;GNP2;GNPDA 2;GNPI2_HUMAN;4921523I18Rik;putative glucosamine-6-phosphate isomerase
Recombinant Proteins
- Rhesus macaque
- Mouse
- Human
- Mammalian Cell
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
GNPDA2 involved in several pathways and played different roles in them. We selected most pathways GNPDA2 participated on our site, such as Amino sugar and nucleotide sugar metabolism,Metabolic pathways,N-acetylglucosamine degradation I, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNPDA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALG1,COX7B,ATP5A1,CYP4A12A,PDHA1A,ACSL3,GALE,ATP6V1G3,MAOA,PTDSS1A |
| Amino sugar and nucleotide sugar metabolism | CYB5R4,CYB5R2,PGM2,PGM1,GFPT1,NANSA,GPR19,FUK,GFPT2,NAGK |
| N-acetylglucosamine degradation II | AMDHD2,GNPDA1 |
| N-acetylglucosamine degradation I | AMDHD2,GNPDA1 |
| UDP-N-acetyl-D-galactosamine biosynthesis II | GNPDA1 |
Protein Function
GNPDA2 has several biochemical functions, for example, glucosamine-6-phosphate deaminase activity,hydrolase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNPDA2 itself. We selected most functions GNPDA2 had, and list some proteins which have the same functions with GNPDA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glucosamine-6-phosphate deaminase activity | GNPDA1 |
| protein binding | FOXO4,RNF180,CCDC120,BRD8,RND1,OLIG3,DNMT3A,SKA1,SNX19,CRYBB3 |
| hydrolase activity | Atp8a2,NUDT13,DHX33,LIPN,PPM1NB,CNOT6L,MOV10B.2,CTSSA,OTUD5A,ADAMTS12 |
Interacting Protein
GNPDA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNPDA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNPDA2.
TRIM27;AMDHD2
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References
- Xi, B; Zhao, XY; et al. An obesity genetic risk score predicts risk of insulin resistance among Chinese children. ENDOCRINE 47:825-832(2014).
- Xi, B; Takeuchi, F; et al. Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis. CLINICAL ENDOCRINOLOGY 81:702-710(2014).
