GNB2L1
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Official Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 -
Overview
Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. -
Synonyms
GNB2L1;guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1;guanine nucleotide-binding protein subunit beta-2-like 1;Gnb2 rs1;H12.3;RACK1;Receptor for Activated C Kinase 1;lung cancer oncogene 7;proliferation-inducing gene 21;human lung cancer oncogene 7 protein;receptor of activated protein kinase C 1;cell proliferation-inducing gene 21 protein;guanine nucleotide-binding protein subunit beta-like protein 12.3;protein homologous to chicken B complex protein, guanine nucleotide binding;HLC-7;PIG21;Gnb2-rs1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- His&MBP
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNB2L1-2655H | Recombinant Human GNB2L1 protein, His-tagged | E.coli | Human | His | 131-317 aa | |
| GNB2L1-1197C | Recombinant Chicken GNB2L1 | Mammalian Cells | Chicken | His |
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| GNB2L1-1375H | Recombinant Human Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1, His-tagged | E.coli | Human | His |
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| GNB2L1-30327TH | Recombinant Human GNB2L1, His-tagged | E.coli | Human | His | Full L. |
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| GNB2L1-465H | Recombinant Human GNB2L1 protein, His&MBP-tagged | E.coli | Human | His&MBP | Met1-Arg317 |
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| GNB2L1-7028M | Recombinant Mouse GNB2L1 Protein | Mammalian Cells | Mouse | His |
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| GNB2L1-9012Z | Recombinant Zebrafish GNB2L1 | Mammalian Cells | Zebrafish | His |
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| GNB2L1-5862HCL | Recombinant Human GNB2L1 293 Cell Lysate | HEK293 | Human | Non |
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| GNB2L1-3767M | Recombinant Mouse GNB2L1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GNB2L1-3767M-B | Recombinant Mouse GNB2L1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GNB2L1 involved in several pathways and played different roles in them. We selected most pathways GNB2L1 participated on our site, such as Androgen receptor signaling pathway,BDNF signaling pathway,CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | HIF3A,COPS5,HIF1AN,NAA10 |
| Androgen receptor signaling pathway | NR2C2,PSMC3IP,ETV5A,PIAS3,HTATIP,DSTN,KDM1A,SMAD3B,SVILA,CMTM2A |
| IL-3 Signaling Pathway | CISH,PILRB,GATA1A,GATA2,KCNIP3B,GATA1,SPI1B,BIRC5A,GSK3AB,GATA2A |
| Interferon type I | PIAS3 |
| Death Receptor Signalling | RBCK1,RNF31,USP4,OTULIN,OTULINB,USP2,TAB1,CLIP3,SHRPRBCK1R,OTUD7B |
| BDNF signaling pathway | EGR1,EGR2,JAK2,DPYSL2,SYN1,LINGO1,EEF2,SIRPA,CDH2,EIF4E |
| IGF1 pathway | GRB10 |
| CXCR4-mediated signaling events | MAPKAP1,GNA13,ARR3,CFL1,PAG1,CSK,ADRBK1,CRK,JAK2,BLK |
Protein Function
GNB2L1 has several biochemical functions, for example, SH2 domain binding,cysteine-type endopeptidase activator activity involved in apoptotic process,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2L1 itself. We selected most functions GNB2L1 had, and list some proteins which have the same functions with GNB2L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | TRMT1L,DIDO1,SUPT5H,TES,RPS17,NQO1,MRPL1,PUF60,CD3EAP,SUMO1 |
| ion channel inhibitor activity | PDZD3,STOML1,RSC1A1,KCNMB2,KCNV1,ENSA |
| protein tyrosine kinase inhibitor activity | IBTK,FGFR1OP |
| protein binding | DCTN1,MGP,TINAGL1,VEGFB,MYOG,WWP2,ZNF433,OPRM1,FBXL14,APPB |
| protein homodimerization activity | ALDH1A3,ASNS,ACHE,MTUS2,MGLL,KIF20B,BAXB,GCA,PAFAH1B1,TCF3 |
| protein kinase C binding | PARD6A,NELL2,HAND2,PEA15A,IRS1,MARCKS,SDC4,ADD3,PAWR,CASQ2 |
| receptor tyrosine kinase binding | Flt3l,PITPNM3,PCNA,GAS6,PTPN1,FIZ1,ANGPT1,PTPN14,HYAL2,SQSTM1 |
| enzyme binding | GSTM3,UGT1A1,KRT79,PARP1,HDHD2,PTPLAD2,ZNHIT6,HSPA6,FAM84B,TSPAN10 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | RPS27L,CARD8,MAPK9,BAD,NLRP12,BCL2L13,CTSC,NOD1,NLRP1,CTSH |
Interacting Protein
GNB2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2L1.
DYNLL1;VHL;PPID;bzlf1_ebvb9
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References
- Guiry, A; Flynn, D; et al. Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar). BMC GENOMICS 11:-(2010).
- Sun, Y; Tao, Y; et al. The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region. NEUROSCIENCE BULLETIN 31:43-52(2015).
