GLS
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Official Full Name
Gls glutaminase -
Overview
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase;that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain;and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter;glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. -
Synonyms
GLS;glutaminase;AI314027;6330442B14;B230365M23Rik
Recombinant Proteins
- Rat
- Chicken
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- His
- His&T7
- Myc&DDK
- His&Fc&Avi
- Flag
- GST
Involved Pathway
GLS involved in several pathways and played different roles in them. We selected most pathways GLS participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,D-Glutamine and D-glutamate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | TNC,VEGFA,NRAS,NOTCH3,APC,ATM,TPM1,MAP2K1,SLC7A1,PDGFRB |
| Central carbon metabolism in cancer | SIRT3,MET,MAPK3,ERBB2,PFKL,G6PD,SLC1A5,MAP2K2,FGFR1,FGFR3 |
| Glutamatergic synapse | SLC38A2,PRKACG,GRM3,PLA2G4C,GNG7,GRIA1,GNAI3,GRIK5,SHANK2,ADRBK2 |
| GABAergic synapse | GNAI3,GABRR1,GNAI2,Adcy4,PRKCA,GNAO1,GABBR2,GAD2,GABRA1,GNB3 |
| Proximal tubule bicarbonate reclamation | PCK1,GLUD1,ATP1A4,SLC25A10,SLC9A3,GLUD2,ATP1B1,SLC38A3,ATP1B4,MDH1 |
| Metabolic pathways | UGT5G1,AMY2A2,ATP6V0A2B,MTR,ZNRD1,CTPS1A,PI4K2B,PDHX,CYP27A1,FDFT1 |
| D-Glutamine and D-glutamate metabolism | GLUD1,GLUD1A,GLUD1B,GLS2,GLSA,GLUD2,ybaS |
| Arginine biosynthesis | GLUD2,GLULA,OTC,GLUL,ybaS,NOS1,GOT2A,GPT2,GOT1,GLUD1 |
| Alanine, aspartate and glutamate metabolism | NAT8L,GLSA,GLULA,GOT2B,FOLH1,RIMKLB,ASPA,PPAT,GPT2,GLUD1B |
Protein Function
GLS has several biochemical functions, for example, glutaminase activity,hydrolase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLS itself. We selected most functions GLS had, and list some proteins which have the same functions with GLS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutaminase activity | GLSA,GLS2,NADSYN1 |
| protein binding | HCLS1,FBXL5,LRP4,BCL11B,MST1,TOP1,RAN,USHBP1,RPS15,KCTD6 |
| hydrolase activity | ST14A,CTS7,REN2,PTPN20,CTSJ,DHX36,LIPN,BPGM,ATP1A1B,NT5DC3 |
Interacting Protein
GLS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLS here. Most of them are supplied by our site. Hope this information will be useful for your research of GLS.
Abcf1
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References
- Taplin, CE; Mojibian, M; et al. Antibodies to the Wheat Storage Globulin Glo-3A in Children Before and at Diagnosis of Celiac Disease. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 52:21-25(2011).
- Simpson, M; Mojibian, M; et al. An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus. PEDIATRIC DIABETES 10:563-572(2009).
