GLDC

  • Official Full Name

    glycine dehydrogenase (decarboxylating)

  • Overview

    Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

  • Synonyms

    GLDC;glycine dehydrogenase (decarboxylating);glycine dehydrogenase (decarboxylating;glycine decarboxylase, glycine cleavage system protein P);glycine dehydrogenase [decarboxylating], mitochondrial;GCSP;glycine cleavage system protein P;glycine deca

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • His
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GLDC-13294H Recombinant Human GLDC, His-tagged E.coli Human His 675-1020a.a.
GLDC-492H Recombinant Human GLDC Protein, His-tagged E.coli Human His Thr81~Asp268
Gldc-494M Recombinant Mouse Gldc Protein, His-tagged E.coli Mouse His Thr521~Phe761
GLDC-394H Recombinant Human GLDC Mammalian Cell Human His
GLDC-5895C Recombinant Chicken GLDC Mammalian Cell Chicken His
GLDC-6397M Recombinant Mouse GLDC Protein Mammalian Cell Mouse His
GLDC-9957Z Recombinant Zebrafish GLDC Mammalian Cell Zebrafish His
GLDC-3039H Recombinant Human GLDC Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
GLDC-3039H-B Recombinant Human GLDC Protein Pre-coupled Magnetic Beads HEK293 Human
GLDC-3591M Recombinant Mouse GLDC Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GLDC-3591M-B Recombinant Mouse GLDC Protein Pre-coupled Magnetic Beads HEK293 Mouse
GLDC-4950H Recombinant Human GLDC Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    GLDC involved in several pathways and played different roles in them. We selected most pathways GLDC participated on our site, such as Glycine, serine and threonine metabolism,Glyoxylate and dicarboxylate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Carbon metabolism DLD,IDH3A,ACADM,DLDH,ALDOC,MDH1,ALDOA,OGDH,GOT2A,TKTL2
    Metabolic pathways GSS,ATP6V0A1B,ACSM4,ITPK1A,HSD17B3,POLR3K,CES1,MAOB,MSMO1,SAT2
    Glyoxylate and dicarboxylate metabolism MDH2,ACO2,GLYCTK,AFMID,DHDPSL,ACO1,CAT,CS,MCEE,AGXT
    Glycine, serine and threonine metabolism AOC3,DMGDH,MAOB,SRR,BPGM,GCSHA,CHDH,PGAM1A,SDS,SHMT2

    Protein Function

    GLDC has several biochemical functions, for example, electron carrier activity,glycine binding,glycine dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLDC itself. We selected most functions GLDC had, and list some proteins which have the same functions with GLDC. You can find most of the proteins on our site.

    Function Related Protein
    electron carrier activity ACADS,GLRX5,MAOB,ETFA,ACOX1,NDUFA12,TXNRD3,GLRX2,ACADL,COX11
    glycine binding GNMT,SIX2A,GLRA4A,GLRA1,ALAS2,GRIN3A,GSS,GRIN1,GRIN2B,GRIN3B
    lyase activity THNSL2,THA1,MOCOS,ECHDC2,Car9,PTGES2,CTHL,CAR1,ADCY1B,ADCY2B

    Interacting Protein

    GLDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLDC here. Most of them are supplied by our site. Hope this information will be useful for your research of GLDC.

    TNIP3;adhB;vacB;q9wmx2-pro_0000037550;ICT1;ULK2

    Resources

    References

    • Martinez-Jacobo, L; Ortiz-Lopez, R; et al. Clinical and molecular delineation of duplication 9p24.3q21.11 in a patient with psychotic behavior. GENE 560:124-127(2015).
    • Kim, HM; Jung, WH; et al. Site-specific metabolic phenotypes in metastatic breast cancer. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).

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