GJA5
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Official Full Name
gap junction protein, alpha 5, 40kDa -
Overview
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are;composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials;from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript;variants encoding the same isoform have been described. -
Synonyms
GJA5;gap junction protein, alpha 5, 40kDa;gap junction protein, alpha 5, 40kD (connexin 40) , gap junction protein, alpha 5, 40kDa (connexin 40);gap junction alpha-5 protein;connexin 40;CX40;connexin-40;ATFB11;MGC11185
Recombinant Proteins
- Human
- Rat
- Chicken
- Bovine
- Dog
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
GJA5 involved in several pathways and played different roles in them. We selected most pathways GJA5 participated on our site, such as Calcium Regulation in the Cardiac Cell,Gap junction assembly,Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction trafficking | DAB2,CX30.3,MYO6A,GJA8,GJD3,GJA4,MYO6B,GJC1,MYO6,GJB4 |
| Vesicle-mediated transport | TBC1D8B,DNASE2,SNX9,SEC22A,GJB5,HPX,TRAPPC2L,CD163,PPP6R1,MYO1C |
| Calcium Regulation in the Cardiac Cell | RGS6,GJC1,ADRA1D,KCNB1,RGS5A,ADRA1B,CX35.4,ADRB2,GJB2,PKIG |
| Gap junction trafficking and regulation | MYO6A,GJA8,MYO6B,GJB3,GJC1,DAB2,GJB7,MYO6,GJA4,CX30.3 |
| Gap junction assembly | GJA4,GJC1,GJB7,GJD3,GJB5,GJB3,GJB2,GJA8,CX27.5,GJB4 |
| Membrane Trafficking | LMAN2,BET1,GAK,GJD3,CX30.3,SNF8,CNO,TCEAL4,PLDN,TGOLN2 |
Protein Function
GJA5 has several biochemical functions, for example, connexin binding,gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling,gap junction channel activity involved in cardiac conduction electrical coupling. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA5 itself. We selected most functions GJA5 had, and list some proteins which have the same functions with GJA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| gap junction channel activity involved in cardiac conduction electrical coupling | GJA1 |
| connexin binding | CXADR,CNSTB,CNST,GJA1,CAV3 |
| gap junction hemi-channel activity | CX35B,CX44.1,CX55.5,PANX1,CX36.7,CX52.6,PANX1A,CX41.8,CX43 |
Interacting Protein
GJA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA5.
MARK1;RIMS3;AAR2
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References
- Lu, ZQ; Sinha, A; et al. Proteomic Analysis of Human Fetal Atria and Ventricle. JOURNAL OF PROTEOME RESEARCH 13:5869-5878(2014).
- Luo, XJ; Huang, L; et al. Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes. SCHIZOPHRENIA BULLETIN 40:1285-1299(2014).
