GEMIN6
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Official Full Name
gem (nuclear organelle) associated protein 6 -
Overview
The survival of motor neurons (SMN) complex is essential for the biogenesis of small nuclear ribonucleoprotein (snRNP) complexes in eukaryotic cells. Reduced levels of SMN cause the motor neuron degenerative disease, spinal muscular atrophy. Complexes containing Gemin3-Gemin4-Gemin5 and Gemin6-Gemin7-unrip persist at similar levels when SMN is reduced. Gemin5-containing subunits bind small nuclear RNA independently of the SMN complex and without a requirement for exogenous ATP. ATP hydrolysis is, however, required for displacement of small nuclear RNAs from the Gemin5-containing subunits and their assembly into snRNPs. -
Synonyms
GEMIN6;gem (nuclear organelle) associated protein 6;gem-associated protein 6;FLJ23459;SIP2;gemin 6;gemin-6
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Strep
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GEMIN6-13224H | Recombinant Human GEMIN6, GST-tagged | E.coli | Human | GST | 1-167a.a. | |
| GEMIN6-5094C | Recombinant Chicken GEMIN6 | Mammalian Cell | Chicken | His |
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| GEMIN6-6302M | Recombinant Mouse GEMIN6 Protein | Mammalian Cell | Mouse | His |
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| GEMIN6-7560H | Recombinant Human GEMIN6, His-tagged | E.coli | Human | His | 1-167aa |
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| GEMIN6-5960HCL | Recombinant Human GEMIN6 293 Cell Lysate | HEK293 | Human | Non |
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| GEMIN6-1260H | Recombinant Human GEMIN6 Protein (M1-Q167), Tag Free | E.coli | Human | Non | M1-Q167 |
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| GEMIN6-1261H | Recombinant Human GEMIN6 Protein (M1-Q167), His/Strep tagged | E.coli | Human | His&Strep | M1-Q167 |
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| Gemin6-3189M | Recombinant Mouse Gemin6 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| GEMIN6-3530M | Recombinant Mouse GEMIN6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GEMIN6-3530M-B | Recombinant Mouse GEMIN6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GEMIN6-4842H | Recombinant Human GEMIN6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GEMIN6-5311HF | Recombinant Full Length Human GEMIN6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 167 amino acids |
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Involved Pathway
GEMIN6 involved in several pathways and played different roles in them. We selected most pathways GEMIN6 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with GEMIN6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | FXR2,EIF2B3,EIF5,EIF4BA,SMN1,SMN,RANGAP1A,NXF1,SUMO2B,DDX20 |
Protein Function
GEMIN6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GEMIN6 itself. We selected most functions GEMIN6 had, and list some proteins which have the same functions with GEMIN6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MTA1,LRRC3,MAP2K3,RARB,PTPN22,ABCG2,DCD,MBD4,ADAM1B,PPFIA4 |
Interacting Protein
GEMIN6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEMIN6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GEMIN6.
GEMIN7;STRAP;TOX4;vpr;JAK3;GPSM2;Smn1;SMN1
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