GCG
-
Official Full Name
glucagon -
Overview
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. -
Synonyms
GCG;GLP 1;GLP 2;GLP-1;GLP-1(7-36);GLP-1(7-37);GLP-2;GLP2;GLUC_HUMAN;glucagon;Glucagon like peptide 1;Glucagon-like peptide 2;GRPP;<br/>OXM;OXY
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Pig
- E.coli
- HEK293
- Mammalian Cell
- Human
- Synthetic
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- Yeast
- His
- Non
- His&T7
- Myc&DDK
- GST
- His&GST
- His&Fc&Avi
- hIgG4
Involved Pathway
GCG involved in several pathways and played different roles in them. We selected most pathways GCG participated on our site, such as Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Insulin secretion | KCNMB2,INS,ATP1B2,PRKCA,PLCB1,SLC2A2,SNAP25,RYR2,PLCB3,ATP1A3 |
Protein Function
GCG has several biochemical functions, for example, hormone activity,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCG itself. We selected most functions GCG had, and list some proteins which have the same functions with GCG. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
receptor binding | PVRL2L,GFRA1,TENM2,ACOT2,CADM4,GNB2L1,CD72,NUDT7,PLAT,NCR3 |
identical protein binding | SMAD6,ASS1,NOL3,HSPB8,ACY3,MICU1,GUCY2E,HAND1,MMP9,BAG2 |
protein binding | POGK,CNOT7,SOX1,ZBTB33,MTMR2,CASQ2,MIS18BP1,TJAP1,PPFIA2,IL15 |
hormone activity | VIP,GH2,SST2,INHBE,EDN3,GIP,FSD1,FAM132A,GAST,METRNL |
Interacting Protein
GCG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCG here. Most of them are supplied by our site. Hope this information will be useful for your research of GCG.
DPP4;FAP;INS;TBC1D1
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References
- Zhu, YT; Ren, XY; et al. Fast identification of lipase inhibitors in oolong tea by using lipase functionalised Fe3O4 magnetic nanoparticles coupled with UPLC-MS/MS. FOOD CHEMISTRY 173:521-526(2015).
- Alisoltani, A; Fallahi, H; et al. RNA-Seq SSRs and small RNA-Seq SSRs: New approaches in cancer biomarker discovery. GENE 560:34-43(2015).