GALNT3
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Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) -
Overview
This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases.The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. -
Synonyms
GALNT3;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3);polypeptide N-acetylgalactosaminyltransferase 3;GalNAc T3;HFTC;HHS;DKFZp686C10199;EC 2.4.1.41;GalNAc transferase 3;GalNAc-T3;GalNAcT3;GALT3_HUMAN;MGC61909;OTTHUMP00000204915;OTTHUMP00000204919;Polypeptide GalNAc transferase 3;Polypeptide N acetylgalactosaminyltransferase 3;pp-GaNTase 3;ppGaNTase 3;Protein UDP acetylgalactosaminyltransferase 3;Protein-UDP acetylgalactosaminyltransferase 3;RP23-306G16.2;UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 3;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3;polypeptide GalNAc-transferase T3
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GALNT3 involved in several pathways and played different roles in them. We selected most pathways GALNT3 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mucin type O-Glycan biosynthesis | GALNT14,GALNT13,GALNT18,GALNTL2,GCNT3,WBSCR17,C1GALT1,GALNT9,GALNT12,C1GALT1B |
| Metabolic pathways | GGT6,PLA2G3,DGAT1,PCYT1A,NDUFV2,BST1,DCTPP1,NDUFS4,ST6GALNAC4,GALNTL6 |
Protein Function
GALNT3 has several biochemical functions, for example, calcium ion binding,carbohydrate binding,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT3 itself. We selected most functions GALNT3 had, and list some proteins which have the same functions with GALNT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | GALNT9,KLRC4-KLRK1,GALNT14,CD209B,NPTX2,Pla2r1,OLR1,BCAN,CLEC9A,ZG16 |
| calcium ion binding | SPNA1,MYL7,VLDLR,SYT10,MYL9,HSP90B1,MFGE8B,EFCAB7,PCDH19,TGM3 |
| protein binding | TSR2,TPD52L3,ZFYVE20,ZNF593,STAT2,KLHL12,C10orf46,CTCFL,SCO1,KCNG3 |
| manganese ion binding | PPEF1,IMPA1,FEN1,MTPAP,FAM20C,LARGE,TDP2,ABL1,PPM1M,NUDT16 |
| polypeptide N-acetylgalactosaminyltransferase activity | GALNT14,GALNT2,GALNT4,GALNT13,GALNT5,C1GALT1C1,GALNT9,GALNT10,WBSCR17,GALNT11 |
Interacting Protein
GALNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT3.
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References
- Ito, N; Wijenayaka, AR; et al. Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:208-218(2015).
- Ghafouri-Fard, S; Abbasi, F; et al. Hyperostosis-hyperphosphatemia syndrome (HHS): report of two cases with a recurrent mutation and review of the literature. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 28:231-235(2015).
