FUT4
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Official Full Name
fucosyltransferase 4 (alpha (1,3) fucosyltranasferase,myeloid-specific) -
Overview
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). -
Synonyms
LeX;CD15;ELFT;FCT3A;FUTIV;SSEA-1;FUC-TIV;FUT4;alpha-(1,3)-fucosyltransferase;Lewis X;fucT-IV;OTTHUMP 00000236888;fucosyltransferase IV;ELAM ligand fucosyltransferase;ELAM-1 ligand fucosyltransferase;galactoside 3-L-fucosyltransferase;stage-specific embryonic antigen 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- Wheat Germ
- His
- His&T7
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FUT4-13044H | Recombinant Human FUT4, His-tagged | E.coli | Human | His | 174-407a.a. | |
| Fut4-1447M | Recombinant Mouse Fut4 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Val144~Phe389 |
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| FUT4-3134C | Recombinant Chicken FUT4 | Mammalian Cells | Chicken | His |
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| FUT4-3288H | Recombinant Human FUT4, His-tagged | E.Coli/Yeast | Human | His | 530 |
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| FUT4-6093M | Recombinant Mouse FUT4 Protein | Mammalian Cells | Mouse | His |
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| FUT4-043H | Recombinant Human FUT4 Protein, C-His-tagged | E.coli | Human | His |
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| FUT4-0700H | Recombinant Human FUT4 Protein (Asp264-Thr497), N-His tagged | E.coli | Human | His | Asp264-Thr497 |
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| FUT4-3393M | Recombinant Mouse FUT4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FUT4-3393M-B | Recombinant Mouse FUT4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FUT4-4166H | Recombinant Human FUT4 Protein (Gly173-Arg530), C-His tagged | Mammalian Cells | Human | His | Gly173-Arg530 |
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| FUT4-4563H | Recombinant Human FUT4 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
FUT4 involved in several pathways and played different roles in them. We selected most pathways FUT4 participated on our site, such as Other types of O-glycan biosynthesis,Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT9A,ST3GAL3,B3GNTL2,B3GALT5,B3GNT4,FUT2,B3GNT1,GCNT2,B3GNT5,B3GNT5A |
| Metabolic pathways | TPH2,ATP6V0A2B,HADHB,MTMR7A,PIPOX,ATP5H,BCO1L,CYP2C50,RGN,GALNT6 |
| Other types of O-glycan biosynthesis | GLT25D1,B4GALT1,POMGNT1,ST3GAL3B,POGLUT1,FUT9A,EOGT,MGAT5B,MFNG,GXYLT2 |
Protein Function
FUT4 has several biochemical functions, for example, alpha-(1->3)-fucosyltransferase activity,fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT4 itself. We selected most functions FUT4 had, and list some proteins which have the same functions with FUT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fucosyltransferase activity | FUT6,4931440L10Rik,B3GNT8,FT1,UGGT1,B3GNTL1,FT2,FUT9,POC1BL,GLT8D1 |
| alpha-(1->3)-fucosyltransferase activity | UGGT1,GALNT18A,B3GNT9,POMGNT2,DPY19L4,B3GNTL1,FUT6,FUT9,FUT3,FUT10 |
Interacting Protein
FUT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT4.
Resources
Research Area
Cardiac Stem Cell MarkersPrimordial Germ Cell Markers
Neutrophils
Neural Stem Cell Markers
Glioma/Medulloblastoma Cancer Stem Cell Markers
Related Services
Related Products
References
- Shan, X; Aziz, F; et al. Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1667-1676(2015).
- Poulain, M; Frydman, N; et al. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. MOLECULAR HUMAN REPRODUCTION 20:960-971(2014).
