FUT3
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Official Full Name
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -
Overview
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. -
Synonyms
FUT3;fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group);fucosyltransferase 3 (galactoside 3(4) L fucosyltransferase, Lewis blood group included) , LE;galactoside 3(4)-L-fucosyltransferase;CD174;MGC131739;alpha (1,3/1,4) fucosyltransferase;Blood group Lewis alpha-4-fucosyltransferase;FT3B;Fucosyltransferase 3;Fucosyltransferase III;FucT-III;FUT3_HUMAN;galactoside 3(4) L fucosyltransferase, Lewis blood group;LE;Les;Lewis B Blood Group antigen;Lewis FT;alpha-(1,3/1,4)-fucosyltransferase
Recombinant Proteins
- Human
- Mammalian cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- His&T7
- Non
- His&Fc&Avi
- GST
Involved Pathway
FUT3 involved in several pathways and played different roles in them. We selected most pathways FUT3 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT9A,ST3GAL3B,FUT7,B3GNT3,ST8SIA1,B3GNTL2,FUT9,ST3GAL4,FUT4,ABO |
| Metabolic pathways | GLS,EBP,AK1,GALNT11,NDUFB5,NDUFA2,DTYMK,DBH,NAT,HMGCL |
Protein Function
FUT3 has several biochemical functions, for example, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity,alpha-(1->3)-fucosyltransferase activity,fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT3 itself. We selected most functions FUT3 had, and list some proteins which have the same functions with FUT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-(1->3)-fucosyltransferase activity | FUT7,FUT11,B3GNT8,B3GNTL1,GALNT18A,GTDC2,GALNTL4,PIGB,4931440L10Rik,B3GNT9-PS |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | FUT6 |
| fucosyltransferase activity | B3GNT9-PS,FUT4,POC1BL,B3GNTL1,DPY19L4,GALNT18A,GTDC2,FUT9D,POMGNT2,FUT7 |
Interacting Protein
FUT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT3.
Resources
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References
- Brazil, JC; Liu, RP; et al. alpha 3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration. JOURNAL OF IMMUNOLOGY 191:4804-4817(2013).
- Silsirivanit, A; Araki, N; et al. CA-S27: A novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma. CANCER SCIENCE 104:1278-1284(2013).
