FOXA1
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Official Full Name
forkhead box A1 -
Overview
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. -
Synonyms
FOXA1;forkhead box A1;hepatocyte nuclear factor 3, alpha , HNF3A;hepatocyte nuclear factor 3-alpha;HNF-3A;TCF-3A;HNF-3-alpha;forkhead box protein A1;transcription factor 3A;hepatocyte nuclear factor 3, alpha;HNF3A;TCF3A;MGC33105
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- Non
- GST
- His
- Myc&DDK
- His&Myc
- His&Fc&Avi
- Flag
Involved Pathway
FOXA1 involved in several pathways and played different roles in them. We selected most pathways FOXA1 participated on our site, such as Direct p53 effectors,FOXA transcription factor networks,FOXA1 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostate Cancer | PDGFB,CREB3L2,NKX3-1,IGF1R,NFKBIA,IGF1,MDM2,ARID1A,Pdgfa&Pdgfb,RELA |
| FOXA1 transcription factor network | NFIA,TFF1,CC10,AP1B1,POU2F1,NRIP1,NFIB,NR2F2,CEBPB,NFIC |
| Direct p53 effectors | CCNK,GDF15,RNF144B,CEBPZ,ZNF385A,SCN3B,DGCR8,BNIP3L,CD82,PRDM1 |
| FOXA2 and FOXA3 transcription factor networks | CEBPA,DLK1,UCP2,CPT1A,KCNJ11,FOXF1,CPT1B,TTR,CPT1C |
Protein Function
FOXA1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA1 itself. We selected most functions FOXA1 had, and list some proteins which have the same functions with FOXA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | NCOA2,PBX2,SMAD2,GTF2A2,RPS3,PIK3R1,HMGB1,DRAP1,HES2,E2F1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | DDIT3,SIX4,ATOH1,EBF2,HOXC13,SOX12,ARID3B,GATA1,MEF2B,POU1F1 |
| transcription factor activity, sequence-specific DNA binding | TBX2B,HEYL,NKX6-2,SREBF1,FOS,FOXE3,BARX1,FLI1A,IRF1A,FOXA2 |
| transcription regulatory region DNA binding | CITED1,ZNF217,THRA,SMAD6,NKX2-1,SP1,MZF1,NKX2,MLL1,YAP1 |
| sequence-specific DNA binding | MSXA,SOX14,HOXC6B,FOXJ1A,HOXB1B,NR3C2,MEIS3,ZSCAN12,TSNAX,ATF6B |
| protein domain specific binding | ACTN2,Ar,DDC,SNCA,TUBA1A,NEFL,STX18,NFE2L2,TBL1X,BHLHE40 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXK1,FOXD4L1,AHR2,PLAGX,ELF2,HIF1AB,FOXC1A,FOXA,FOXD5,SPI1A |
| DNA binding | HOXD3,ZNF385A,CERS5,SSBP3B,ZNF433,FOXG1D,PBX1,POU5F1,MEF2CB,TWIST2 |
Interacting Protein
FOXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA1.
RARA;AR;SEZ6L2;FOXC1;erbb3_human_gene;myc_human_gene;GREB1;ESR1;TBP;GATA3;FOXA2
Resources
Research Area
Hepatic Progenitor Cell Transcription FactorsHepatic and Pancreatic Progenitor Cell Transcription Factors
Related Services
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References
- Hu, ZH; Zhu, LC; et al. The expression and correlation between the transcription factor FOXP1 and estrogen receptors in epithelial ovarian cancer. BIOCHIMIE 109C:42-48(2015).
- Seksenyan, A; Kadavallore, A; et al. TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer. BMC CANCER 15:-(2015).
