FOSB

  • Official Full Name

    FBJ murine osteosarcoma viral oncogene homolog B

  • Overview

    The Fos family of nuclear oncogenes includes c-Fos, FosB, Fos-related antigen 1 (FRA1), and Fos-related antigen 2 (FRA2). While most Fos proteins exist as a single isoform, the FosB protein exists as two isoforms: full-length FosB and a shorter form, FosB

  • Synonyms

    FOSB;FBJ murine osteosarcoma viral oncogene homolog B;protein fosB;activator protein 1;AP 1;DKFZp686C0818;GOS3;GOSB;G0S3;MGC42291;oncogene FOS B;G0/G1 switch regulatory protein 3;AP-1

Recombinant Proteins

  • Human
  • Zebrafish
  • E.coli
  • E. coli
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
FOSB-12964H Recombinant Human FOSB, GST-tagged E.coli Human GST 2-14a.a.
FOSB-02H Recombinant Full Length Human FOSB Protein, His tagged E. coli Human His Full L. 1-338 aa
FOSB-1230H Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog B E.coli Human Non
FOSB-1303H Recombinant HumanFOSB,GST-tagged,113-151aa E.coli Human GST
FOSB-1704Z Recombinant Zebrafish FOSB Mammalian Cell Zebrafish His
FOSB-28107TH Recombinant Human FOSB E.coli Human Non 113-151 a.a.
FOSB-6167HCL Recombinant Human FOSB 293 Cell Lysate HEK293 Human Non
FOSB-01H Recombinant Human FOSB Protein, His-tagged E.coli Human His 1-255 a.a.
FOSB-4425H Recombinant Human FOSB Protein, GST-tagged Wheat Germ Human GST
FOSB-5040HF Recombinant Full Length Human FOSB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 289 amino acids

    Involved Pathway

    FOSB involved in several pathways and played different roles in them. We selected most pathways FOSB participated on our site, such as Osteoclast differentiation,Cocaine addiction,Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Osteoclast differentiation MAP2K6,AKT1,IFNGR2,RAC1,LCK,TRAF6,FYN,CSF1R,TREM2,MAPK12
    Cocaine addiction PDYN,GRIN2B,DRD1,GRM3,ATF6B,GRIA2,GPSM1,PRKACA,SLC18A1,DRD2
    Alcoholism CREB3L4,HIST1H3E,RAF1,HIST1H2AJ,GM6026,NPY,NTRK2,HIST1H2BA,HIST1H3D,HIST1H2AC

    Protein Function

    FOSB has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOSB itself. We selected most functions FOSB had, and list some proteins which have the same functions with FOSB. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZNF217,TLX1,NPAS4,POU2F2,MAX,PDX1,TCF7L2,BSX,ZNF460,ISL1
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding HIST2H3A,RBPJA,BATF,BATF2,FOSL2,ATF3,CREB3,FOSL1A,CLOCK,RBPJB
    DNA binding POLD2,MKXB,STAT2,KCNIP3,ZNF2,EVE1,NKX1.2LB,NR2F1A,PIAS1,LUC7L3
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MYOG,TFE3B,CREB1,CDX4,ETV2,NFATC2,TLX1,ONECUTL,SIX2,ETV4
    transcription factor binding DOT1L,RNF4,SOX10,TCF7L2,DNAJA3,ATG7,TFDP1,POU5F1,CEBPG,LEF1

    Interacting Protein

    FOSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOSB here. Most of them are supplied by our site. Hope this information will be useful for your research of FOSB.

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    Resources

    Research Area

    Apoptosis Transcription Factors and Regulators
    Cancer Stem Cell Transcription Factors
    Neural Stem Cell Transcription Factors

    References

    • Desai, BN; Harris, RBS; et al. Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 308:E351-E361(2015).
    • Saxena, A; Little, JT; et al. Angiotensin II type 1a receptors in subfornical organ contribute towards chronic intermittent hypoxia-associated sustained increase in mean arterial pressure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H435-H446(2015).

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