FNTA
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Official Full Name
farnesyltransferase, CAAX box, alpha -
Overview
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. -
Synonyms
FNTA;farnesyltransferase, CAAX box, alpha;protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha;FPTA;PGGT1A;protein prenyltransferase alpha subunit repeat containing 2;PTAR2;FTase-alpha;GGTase-I-alpha;farnesyl-protein transfe
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FNTA involved in several pathways and played different roles in them. We selected most pathways FNTA participated on our site, such as Terpenoid backbone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FNTA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Terpenoid backbone biosynthesis | HMGCR,ZMPSTE24,HMGCRA,ICMT,IDI2,PDSS2,FNTB,ACAT1,PMVK,MVDA |
Protein Function
FNTA has several biochemical functions, for example, contributes_to CAAX-protein geranylgeranyltransferase activity,Rab geranylgeranyltransferase activity,acetylcholine receptor regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FNTA itself. We selected most functions FNTA had, and list some proteins which have the same functions with FNTA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to protein farnesyltransferase activity | FNTB |
| protein geranylgeranyltransferase activity | UBIAD1,PGGT1B |
| acetylcholine receptor regulator activity | AGRN |
| protein farnesyltransferase activity | FNTB |
| Rab geranylgeranyltransferase activity | RABGGTB,RABGGTA |
| microtubule binding | KIFC1,MAPRE1B,MAP1B,NUMA1,GAS2L1,SNCA,DPYSL5B,CAMSAP1,MTAP6,CEP57L1 |
| alpha-tubulin binding | PROL1,C9orf24,ARL8A,WASH,WASH1,DDL-2,NDEL1,SNCA,SERPINB1A,FAM110C |
| contributes_to CAAX-protein geranylgeranyltransferase activity | PGGT1B |
| receptor tyrosine kinase binding | FLT3LG,SHC3,Flt3l,NRG1,PTPN2,TRP53,TP53,SOCS5,HYAL2,GAS6 |
Interacting Protein
FNTA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FNTA here. Most of them are supplied by our site. Hope this information will be useful for your research of FNTA.
FNTB;PTP4A3;RAP2A;PTP4A2;INHBB;TGM2;RPL13A;STAT2;VAV2;SAFB2;sbcB;q5nig6_fratt;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate
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References
- Nguyen, CH; Watts, VJ; et al. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: Implications for adenylyl cyclase 2 signaling. MOLECULAR PHARMACOLOGY 69:1763-1771(2006).
- Si, XN; Zeng, Q; et al. Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. JOURNAL OF BIOLOGICAL CHEMISTRY 276:32875-32882(2001).
