FKBP14
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Official Full Name
FK506 binding protein 14, 22 kDa -
Overview
The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans;isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate;protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding;variant and noncoding variants are transcribed from this gene. -
Synonyms
FKBP14;FK506 binding protein 14, 22 kDa;FK506 binding protein 14 (22 kDa);peptidyl-prolyl cis-trans isomerase FKBP14;FKBP22;FLJ20731;22 kDa FK506 binding protein;22 kDa FK506-binding protein;22 kDa FKBP;FK506 binding protein 14;FK506-binding protein 14;FKB14_HUMAN;FKBP 22;FKBP-14;FKBP-22;Peptidyl prolyl cis trans isomerase;PPIase;PPIase FKBP14;Rotamase;OTTHUMP00000122625
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Human Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
FKBP14 involved in several pathways and played different roles in them. We selected most pathways FKBP14 participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | SERPINA7,PFDN2,ALG10B,TBCA,IGFBP2,NAT8,EEF1D,SEC61B,PFDN4,MLEC |
| XBP1(S) activates chaperone genes | WIPI1,HDGF,CTDSP2,ASNA1,KLHDC3,SERP1,KDELR3,YIF1A,PDIA6,DNAJB9 |
| IRE1alpha activates chaperones | SERP1,CTDSP2,DNAJB9,SEC63,ASNA1,PREB,DDX11,C19orf10,CXXC1,TPP1 |
| Unfolded Protein Response (UPR) | HDGF,CXXC1,KLHDC3,KDELR3,ASNA1,PDIA6,DDX11,CTDSP2,SEC63,TPP1 |
Protein Function
FKBP14 has several biochemical functions, for example, FK506 binding,calcium ion binding,peptidyl-prolyl cis-trans isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP14 itself. We selected most functions FKBP14 had, and list some proteins which have the same functions with FKBP14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | THBS4,BMP1,CBL,HPCAL4,SCUBE1,NKD2,ATP2C1,REPS1,PCDHGA4,ICN |
| FK506 binding | FKBP10B,FKBP10,FKBP8,FKBP2,FKBPL,FKBP1AA,NFATC1,FKBP1B,FKBP3,FKBP6 |
| peptidyl-prolyl cis-trans isomerase activity | PPIE,PPIFB,PPIFA,TTC9B,PPIB,FKBP10B,PPWD1,FKBP3,PPID,RANBP2 |
Interacting Protein
FKBP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP14.
POLR2E;GSK3B;HIST2H4B
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