FGFRL1
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Official Full Name
fibroblast growth factor receptor-like 1 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. -
Synonyms
FGFRL1;fibroblast growth factor receptor-like 1;FGF homologous factor receptor;FGF receptor like protein 1;FGFR 5;FGFR like protein;FGFR5;FHFR;Fibroblast growth factor receptor 5;Fibroblast growth factor receptor like 1;FGFR-5;FGFR-like protein;FGF receptor-like protein 1
Recombinant Proteins
- Mouse
- Rat
- Chicken
- Human
- HEK293
- Mammalian cells
- Mammalian Cell
- Human Cell
- Rabbit
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Fc
- Non
- His&T7
- His&Fc&Avi
- GST
Involved Pathway
FGFRL1 involved in several pathways and played different roles in them. We selected most pathways FGFRL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFRL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FGFRL1 has several biochemical functions, for example, fibroblast growth factor binding,fibroblast growth factor-activated receptor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFRL1 itself. We selected most functions FGFRL1 had, and list some proteins which have the same functions with FGFRL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | SLIT2,APOA5,COL13A1,POSTN,CCL23,BMP7,LTBP2,PF4V1,PTPRFB,REG4 |
| fibroblast growth factor-activated receptor activity | FGFR1B,FGFR1,FGFR1A,FGFR3,FGFR4,FGFR2 |
| fibroblast growth factor binding | GLG1B,FGFR1A,FGFBP3,RPS19,GPC1,CXCL13,PTPRZ1,FGFBP1,FGFR4,TGFBR3 |
Interacting Protein
FGFRL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFRL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFRL1.
Resources
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References
- Matoso, E; Ramos, F; et al. Interstitial 287 kb deletion of 4p16.3 including FGFRL1 gene associated with language impairment and overgrowth. MOLECULAR CYTOGENETICS 7:-(2014).
- Donnard, E; Asprino, PF; et al. Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy. ONCOTARGET 5:9199-9213(2014).
