FGFR1OP
-
Official Full Name
FGFR1 oncogene partner -
Overview
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified. -
Synonyms
FGFR1OP;FGFR1 oncogene partner;FOP;Fibroblast growth factor receptor 1 oncogene partner;OTTHUMP00000017612;OTTHUMP00000017613
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- Avi
Involved Pathway
FGFR1OP involved in several pathways and played different roles in them. We selected most pathways FGFR1OP participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR1OP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | NUPL2,NPM1,CEP78,GOLGA2,ACTR1A,RBBP4,SKP1,CDK1,YWHAQB,NSL1 |
| Diseases of signal transduction | OS9,OPN1SW,OPN1LW,HEY2,STRA6,CDC37,JAG1,CPSF6,TRAT1,JAG2 |
| Disease | CPSF4,KREMEN2,WHSC2,SUPT5H,GPC5,CUX1,FMOD,CCDC59,gag,PRELP |
| Centrosome maturation | CDK11A,MAPRE1,CCP110,CEP72,NEDD1,TSGA14,TUBB4A,TUBG2,CEP164,CEP63 |
| Anchoring of the basal body to the plasma membrane | ACTR1A,CEP76,CSNK1E,TTBK2,DYNC1I2,CEP89,FBF1,DCTN3,CETN2,NDE1 |
| Cell Cycle, Mitotic | POLD3,ENSAB,CEP164,CCP110,NIPBLA,CTDNEP1,SGOL2,STIL,TCTN2,CKS1B |
| Assembly of the primary cilium | NDE1,IFT22,CDK5RAP2,TUBG1,SETD6,IFT20,EXOC1,DYNLL2A,CSNK1D,SSNA1 |
| FGFR1 mutant receptor activation | CPSF6,LRRFIP1,MYO18A,CUX1,FGFR1OP2,TRIM24 |
Protein Function
FGFR1OP has several biochemical functions, for example, protein binding,protein homodimerization activity,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR1OP itself. We selected most functions FGFR1OP had, and list some proteins which have the same functions with FGFR1OP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | HINT2,MAP3K12,DDX1,TFAP4,P2RX7,BST2,GSTM1,Bcl2a1b,DMRTC2,DARS2 |
| protein tyrosine kinase inhibitor activity | GNB2L1,IBTK |
| protein kinase binding | KIF13B,BCAR1,PTK2,PRKAG1,RAD9A,FZD5,KIF11,RAB11FIP2,C10orf46,RACGAP1 |
| protein binding | TREX1,C1orf35,PMF1,ZNF488,MGST1,GNAQ,HNRNPA1,SAV1,DMAP1,SUMO3 |
| protein tyrosine kinase activity | FGFR3,SRMS,FYNA,PTK2AA,MAP3K9,AXL,ERBB4,MAP2K1,FYNB,ERBB4A |
Interacting Protein
FGFR1OP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR1OP here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR1OP.
VASP;CEP19;PPP2CB;CTGF;CEP350;PACS1;NAGK;CEP350;CCHCR1;Lrrcc1;TBC1D31;PCM1;CSPP1;CCDC14
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