FGF5
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Official Full Name
fibroblast growth factor 5 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
FGF5;fibroblast growth factor 5;heparin-binding growth factor 5;HBGF-5;Smag-82
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E. coli
- Non
- His
- His&GST
- His&Fc&Avi
- GST
- N-His-GST&C-Myc
- N-His&C-Myc
Involved Pathway
FGF5 involved in several pathways and played different roles in them. We selected most pathways FGF5 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF7,RAC1B,SRFA,MAPK12,RPS6KA4,FAS,PPP3CA,TGFB3,FASLG,HSP70 |
| PIK-Akt signaling pathway | MLST8,INS,ITGB4,Fasl,LAMA4,TSC1,PKN3,LPAR3,GRB2,LAMA5 |
| Pathways in cancer | FZD2,BRAF,RBX1,CDC42,GRB2,LAMB2,SPI1,NFKB1,BDKRB2,GNAI3 |
| Melanoma | FGF8,PDGFA,PIK3R3,PIK3CA,TRP53,FGF17,BRAF,IGF1R,FGF7,AKT2 |
| Regulation of Actin Cytoskeleton | MYL1,INS2,PAK1,FGF6A,BAIAP2A,PPP1R12A,ARHGAP35,VAV2,WAS,BCAR1 |
| Ras signaling pathway | RRAS2,PIK3R1,MAPK1,RAB5C,INS,STK4,FGF19,MET,VEGFC,Fasl |
| Rap signaling pathway | ANGPT1,ITGB2L,FGF22,VAV2,LPAR5,RAPGEF6,MAGI2,CALM3,PFN3,PIK3CB |
Protein Function
FGF5 has several biochemical functions, for example, fibroblast growth factor receptor binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF5 itself. We selected most functions FGF5 had, and list some proteins which have the same functions with FGF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | NENF,NRG2,Il2,FGF10A,MDK,THBS4B,EPGN,Kitl,OGN,GDF6 |
| fibroblast growth factor receptor binding | FGF20B,FGF21,FGF8,FGF16,FGF8B,Fgf15,FGF6,FGF20,FGF10B,FGF20A |
Interacting Protein
FGF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF5.
EGF;FGFR2;FGFR4;MAPK1
FGF5 Related Signal Pathway
Resources
Research Area
Early Mesodermal Lineage MarkersFGF Family
Embryonic and Induced Pluripotent Stem Cell Markers
FGF Ligands
Fibroblast Growth Factor (FGF)
Ectodermal Lineage Markers
Mesodermal Lineage Markers
Related Services
Related Products
References
- Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).
- Hirano, K; Van Kuppevelt, TH; et al. The transition of mouse pluripotent stem cells from the naive to the primed state requires Fas signaling through 3-O sulfated heparan sulfate structures recognized by the HS4C3 antibody. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430:1175-1181(2013).
