FGF14
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Official Full Name
fibroblast growth factor 14 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
FGF14;fibroblast growth factor 14;FHF4;SCA27;MGC119129;MGC129319;bA397O8.2;FHF 4;Fibroblast growth factor homologous factor 4;mFHF-4(1B);MGC129318;RP11-397O8.6;FHF-4;FGF-14
Recombinant Proteins
- Rat
- Canine
- Human
- Zebrafish
- Mouse
- Chicken
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FGF14 involved in several pathways and played different roles in them. We selected most pathways FGF14 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | PDGFB,MYL1,ITGB2,PIP5K1AB,RASSF7,MAPK6,FGF10,PIK3R1,VAV1,FGF18 |
| MAPK signaling pathway | RPS6KA1,FGF18A,NLK1,DUSP8A,FGFR1,MAP4K4,NLK,Fasl,TGFBR2,IL1R2 |
| PIK-Akt signaling pathway | Fasl,IFNA21,THBS1,Fgf15,Pdgfa&Pdgfb,LAMB2,IFNA5,PPP2R3A,THBS3,VTN |
| Ras signaling pathway | ABL2,PLD2,BRAP,GRIN2A,MAPK1,RAB5B,SHC3,FGF9,NFKB1,INS1 |
| Rap signaling pathway | CDC42,MAGI2,CALML3,PRKCA,MAP2K6,RAC1,RHOA,ANGPT1,IGF1,FGF20 |
| Pathways in cancer | PRKACB,PPARG,SPI1,PDGFRA,TGFB2,TFG,SMO,FZD8,EGLN1,ABL1 |
| Melanoma | FGF16,PIK3CA,FGF22,RAF1,HRAS,AKT2,FGF19,PIK3R2,PIK3CB,FGF11 |
Protein Function
FGF14 has several biochemical functions, for example, NOT fibroblast growth factor receptor binding,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF14 itself. We selected most functions FGF14 had, and list some proteins which have the same functions with FGF14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | GRN,OSGIN1,NUDT6,KITLG,GDF5,GDNF,BMP8B,FGF24,FGF1A,GSDF |
| NOT fibroblast growth factor receptor binding | FGF12 |
| heparin binding | LIPG,FGF1,LXN,ADAMTS8,RSPO2,THBS1,BMP7,CTGFB,WISP3,PDCD5 |
Interacting Protein
FGF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF14.
HIST1H3D
FGF14 Related Signal Pathway
Resources
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References
- Hsu, WC; Nenov, MN; et al. Identifying a Kinase Network Regulating FGF14:Nav1.6 Complex Assembly Using Split-Luciferase Complementation. PLOS ONE 10:-(2015).
- Yan, HD; Pablo, JL; et al. FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons. ELIFE 3:-(2014).
