FGB
-
Official Full Name
fibrinogen beta chain -
Overview
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. -
Synonyms
FGB;fibrinogen beta chain;fibrinogen, B beta polypeptide;MGC104327;MGC120405
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Cattle
- Mouse
- Dog
- Bovine
- Cat
- Pig
- Horse
- Rabbit
- Mammalian Cell
- E.coli
- HEK293
- Rat plasma
- Bovine Plasma
- Dog Plasma
- Wheat Germ
- Porcine plasma
- Rabbit Plasma
- Human plasma
- Non
- His
- His&S
- His&Fc&Avi
- N-His-KSI
- GST
Involved Pathway
FGB involved in several pathways and played different roles in them. We selected most pathways FGB participated on our site, such as Complement and coagulation cascades,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | BTK,MAPK3,P2RX1,PLCB4,PRKG1,ITGB3,PIK3CA,PLCB1,APBB1IP,GUCY1B3 |
| Complement and coagulation cascades | SERPINC1,CD59A,C8G,FGA,C1QB,PLAU,F12,CFH,CD59,THBD |
Protein Function
FGB has several biochemical functions, for example, contributes_to cell adhesion molecule binding,chaperone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGB itself. We selected most functions FGB had, and list some proteins which have the same functions with FGB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to cell adhesion molecule binding | FGA |
| structural molecule activity | COPE,LCE4A,VCL,CLDNB,LELP1,KRT32,NEFH,CLDN9,KRT3,KLHL3 |
| protein binding | CALM2,SALL1,CDK20,VWF,FGF3,TDG,SENP5,UVRAG,FAM72A,FABP2 |
| protein binding, bridging | FSCN2B,CUX1,EVPL,ANK2,GATAD2A,FSCN3,COL1A2,ST13,CNTLN,COL8A2 |
| contributes_to receptor binding | FGA |
| chaperone binding | GNB5,HSP104,DLST,PFDN4,CALR,BAK1,AHSA2,HSPA5,ATP1A2,DNLZ |
Interacting Protein
FGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGB here. Most of them are supplied by our site. Hope this information will be useful for your research of FGB.
FGA;p27958-pro_0000037566;KLK6;MIS12;GAMMAHV.ORF10;TK1;ANXA7;p29991-pro_0000037940;p29991-pro_0000308465;CDKN1A;CSNK2B;BKLF1;AIMP2;GRB7;SMN1;PIK3R3
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References
- Luyckx, VA; Cairo, LV; et al. Oncostatin M pathway plays a major role in the renal acute phase response. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 296:F875-F883(2009).
- Linden, M; Segersten, U; et al. Tumour expression of bladder cancer-associated urinary proteins. BJU INTERNATIONAL 112:407-415(2013).
