FCN2
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Official Full Name
ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) -
Overview
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
FCN2;ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin);ficolin-2;collagen/fibrinogen domain containing protein 2;EBP 37;FCNL;ficolin B;ficolin 2;hucolin;L ficolin;P35;serum lectin p35;37 kDa elastin-binding protein;Ficolin beta;OTTHUMP00000022518;RP11-263F14.2;L-ficolin;ficolin-B;ficolin-beta;collagen/fibrinogen domain-containing protein 2;EBP-37
Recombinant Proteins
- Human
- Rhesus macaque
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Yeast
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FCN2 involved in several pathways and played different roles in them. We selected most pathways FCN2 participated on our site, such as Complement cascade,Creation of C4 and C2 activators,Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ficolins bind to repetitive carbohydrate structures on the target cell surface | FCN1,MASP2,FCN3 |
| Immune System | SIRPB1,CD300A,KIF5A,BTR22,CTSE,ASB18,LILRB5,DEFB125,IFIT14,SIGIRR |
| Innate Immune System | DDOST,CTS7,BFB,BTR06,SUGT1,CYLD,RCA2.1,CLEC4A,CD180,NLRP4C |
| Initial triggering of complement | C1rb,CRP,IgG3,GZMM,FCN3,FCN1,CFD,BFB,MASP2,HBL3 |
| Creation of C4 and C2 activators | IGKC,FCN3,MASP2,C1rb,IGKV1-5,IgG3,CRP,FCN1,HBL3,IGLC2 |
| Lectin pathway of complement activation | FCN3,FCN1,HBL3 |
| Complement cascade | CFHL2,FCN1,CFHL3,CFHL4,CR1,IgG3,MASP2,IGLC2,HBL3,GZMM |
Protein Function
FCN2 has several biochemical functions, for example, antigen binding,calcium-dependent protein binding,mannan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN2 itself. We selected most functions FCN2 had, and list some proteins which have the same functions with FCN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mannan binding | REG4 |
| calcium-dependent protein binding | CALM1,ANXA6,S100A6,CD209A,CHP,MYO5A,VPS37C,SYN1,TSG101,TNNT3 |
| protein binding | PRAP1,JUND,PPP1R2P9,APOBEC3C,CASP2,ENOX2,KDRL,HIST1H2AM,GSTK1,SPHK2 |
| proteoglycan binding | NID1,CTSB,CTSS,CECR1,THBS1,COL5A1,CECR1A,CTSK,UBE4A,SLIT2 |
| antigen binding | Ighg2a,LILRB4,FCN3,TSPAN4,TGFB1,CD40,IGKV1-5,TOPORS,LAG3,MHC1UKA |
Interacting Protein
FCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN2.
LRP1;CRP;q9wmx2-pro_0000037550
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References
- Metzger, ML; Michelfelder, I; et al. Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:256-264(2015).
- Osthoff, M; Irungu, E; et al. Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine. VACCINE 32:4772-4777(2014).
