FBXW7
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Official Full Name
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the genes potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] -
Synonyms
FBXW7;F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase;AGO;CDC4;FBW6;FBW7;hAgo;FBX30;FBXW6;SEL10;hCdc4;FBXO30;SEL-10;F-box/WD repeat-containing protein 7;archipelago;F-box protein FBW7;F-box protein FBX30;F-box protein SEL-10;homolog of C elegans sel-10;F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- His&T7
Involved Pathway
FBXW7 involved in several pathways and played different roles in them. We selected most pathways FBXW7 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | ANAPC11,PRPF19,SMURF1,UBE2M,ANAPC7,UBE2Z,HERC3,UBE2IB,UBE2G1B,PARK2 |
Protein Function
FBXW7 has several biochemical functions, for example, cyclin binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW7 itself. We selected most functions FBXW7 had, and list some proteins which have the same functions with FBXW7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin binding | CDK13,CDK14,CDK12,CDK6,INCA1,CDK5RAP3,CDK4,PFTK1,CDK2,MDFIC |
| identical protein binding | CNTN2,ATL1,BTK,RIPK3,FBP1,EPHA4,Serpina1b,COL7A1,TARDBP,HOOK3 |
| ubiquitin protein ligase binding | RNF31,RAD18,TRIM37,CUL1A,UBE2G1B,KCNH2,CASP8,ASB4,CDKN1A,NFKBIA |
| ubiquitin-protein transferase activator activity | RING1,AUP1,UBE2L3,CBX8 |
| transcription factor activity, sequence-specific DNA binding | RCOR2,RFX8,ZNF454,POU2F1A,RXRAB,HMG20A,E2F3,FOXP3,ETV5B,CBFA2T2 |
| protein binding | NETO2,CHD7,SPA17,DHRS1,PCTP,RCOR1,SFPI1,DPY30,GPA33,KRTAP9-4 |
| protein binding, bridging | TRIM6,FSCN2B,TRIM5,TJP2,IVL,NCK1,CRADD,EVPL,WWC1,TNNT2A |
Interacting Protein
FBXW7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW7.
SKP1;MYC;CCNE1;CCDC6
FBXW7 Related Signal Pathway
Resources
Research Area
Tumor SuppressorsNotch Family
E3 Ubiquitin Ligases
Post-translational Modification of NFkB/IkB
Ubiquitin-Proteasome Pathway
Related Services
Related Products
References
