FBXW11
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Official Full Name
F-box and WD-40 domain protein 11 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. -
Synonyms
FBXW11;F-box and WD-40 domain protein 11;F-box/WD repeat-containing protein 11;homologous to Slimb protein;F-box and WD-40 domain protein 1B;F-box/WD repeat-containing protein 1B;F-box and WD repeats protein beta-TrCP2;HOS;BTRC2;BTRCP2;Fbxw1b;A
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- Non
- His
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
FBXW11 involved in several pathways and played different roles in them. We selected most pathways FBXW11 participated on our site, such as Oocyte meiosis,Ubiquitin mediated proteolysis,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXW11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | FZD3B,DAAM2,SFRP4,CCND2,WNT11R,FZD8A,PSEN1,PRKACAA,MAPK10,FOSL1A |
| Hedgehog signaling pathway | WNT4,GLI2A,RAB23,ZIC2B,PTCH2,GAS1,WNT5A,WNT6,SAP18,BTRC |
| Ubiquitin mediated proteolysis | SIAH2L,UBE2D4,SKP2,PARK2,UBE2NA,TRAF6,SMURF1,VHL,UBE2J1,UBE2G1A |
| Hippo signaling pathway | SMAD3,LEF1,YWHAH,WNT9B,AXIN2,TCF7L2,PARD6A,BMP8A,TEAD3,SAV1 |
| Shigellosis | ROCK1,WASF1,RAC1,ACTG1,VCL,MAPK9,MAD2L2,ITGA5,MAPK12,NFKB1 |
| Circadian rhythm | PRKAG3,ARNTL,NR1D1,BHLHE40,PER2,CRY2,PER3,RORB,CSNK1E,PER1 |
| Oocyte meiosis | PPP2R5CB,PRKACAB,RPS6KA6,CALM4,ITPR3,CALML5,PPP2CB,PRKACB,CALM1A,CAMK2B1 |
Protein Function
FBXW11 has several biochemical functions, for example, protein binding,protein dimerization activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXW11 itself. We selected most functions FBXW11 had, and list some proteins which have the same functions with FBXW11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAPK12,RNF41,PEX12,ITGA2,NPM2,GNG12,RBL2,ARHGAP44,ITGA1,POLR2A |
| ubiquitin-protein transferase activity | TRIM27,UBE2D2A,UBE2G1,RNF125,RBBP6,IRAK1,SIAH1A,RNF31,RNF13,DZIP3 |
| protein dimerization activity | POLR1D,TCF3B,HER11,LDB1A,ASCL3,MYCLA,MESPBA,TCF23,ID2B,MESPAB |
| ubiquitin protein ligase activity | HERC2,RNF144AB,STUB1,RNF146,TRAF6,RNF126,TRIM63,HERC3,PARK2,UBE3B |
Interacting Protein
FBXW11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXW11 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXW11.
SKP1;CUL1;IFNAR1;WEE1
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