FBXO32
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Official Full Name
F-box protein 32 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
FBXO32;F-box protein 32;F box only protein 32;F-box only protein 32;ATROGIN1;Fbx32;MAFbx;4833442G10Rik;AI430017;Atrogin 1;Atrogin-1;Atrophy gene 1;FBX32_HUMAN;fbxo25;FLJ32424;MGC108443;MGC137646;MGC33610;Muscle atrophy F box;Muscle atrophy F box protein;Muscle atrophy F-box protein
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXO32-12796H | Recombinant Human FBXO32, GST-tagged | E.coli | Human | GST | C-term-217a.a. | |
| FBXO32-237H | Recombinant Human FBXO32 Protein, His-tagged | E.coli | Human | His | Met1~Glu201 | |
| FBXO32-3647H | Recombinant Human FBXO32 protein, His-tagged | E.coli | Human | His | 1-216 aa | |
| FBXO32-3801H | Recombinant Human FBXO32 protein, His-tagged | E.coli | Human | His | 50-120 aa | |
| FBXO32-11158Z | Recombinant Zebrafish FBXO32 | Mammalian Cell | Zebrafish | His |
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| FBXO32-1663R | Recombinant Rhesus monkey FBXO32 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| FBXO32-2295R | Recombinant Rat FBXO32 Protein | Mammalian Cell | Rat | His |
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| FBXO32-22H | Recombinant Human FBXO32 protein, His-tagged | E.coli | Human | His |
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| FBXO32-2644C | Recombinant Chicken FBXO32 | Mammalian Cell | Chicken | His |
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| FBXO32-28812TH | Recombinant Human FBXO32 | Wheat Germ | Human | Non | 210 amino acids |
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| FBXO32-3936H | Recombinant Human FBXO32 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXO32-5744M | Recombinant Mouse FBXO32 Protein | Mammalian Cell | Mouse | His |
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| FBXO32-6297HCL | Recombinant Human FBXO32 293 Cell Lysate | HEK293 | Human | Non |
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| FBXO32-1487R | Recombinant Rhesus Macaque FBXO32 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| FBXO32-1487R-B | Recombinant Rhesus Macaque FBXO32 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| FBXO32-165HF | Recombinant Full Length Human FBXO32 Protein | In Vitro Cell Free System | Human | Full L. 210 amino acids |
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| FBXO32-1952R | Recombinant Rat FBXO32 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| FBXO32-1952R-B | Recombinant Rat FBXO32 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| FBXO32-3160M | Recombinant Mouse FBXO32 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FBXO32-3160M-B | Recombinant Mouse FBXO32 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FBXO32-4670HF | Recombinant Full Length Human FBXO32 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 210 amino acids |
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| Fbxo32-4916M | Recombinant Mouse Fbxo32 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 1-355aa |
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Involved Pathway
FBXO32 involved in several pathways and played different roles in them. We selected most pathways FBXO32 participated on our site, such as FoxO family signaling,FoxO signaling pathway,Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | ATM,PTEN,RAG2,GADD45G,CCNG2,PRKAG3B,G6PCA.1,IRS4,INS2,MAPK14A |
| Monoamine Transport | HRH3,SYN1,TPH2,UNC13B,TGFB1I1,DBH,SCAMP2 |
| FoxO family signaling | CSNK1G2,CSNK1G3,ZFAND5,MST1,GADD45A |
Protein Function
FBXO32 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO32 itself. We selected most functions FBXO32 had, and list some proteins which have the same functions with FBXO32. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RPN1,HSD17B12,PBX1,CLOCKA,FGF7,TBL1X,COX5B,LACTB2,CHIC2,C2orf51 |
Interacting Protein
FBXO32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO32 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO32.
EIF3F;MYOG;MLH1;SKP1;KDM2A
Resources
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References
- Cappelletti, C; Galbardi, B; et al. Autophagy, Inflammation and Innate Immunity in Inflammatory Myopathies. PLOS ONE 9:-(2014).
- Ma, L; Shen, CA; et al. EXTRACELLULAR SIGNAL-REGULATED KINASE-MAMMALIAN TARGET OF RAPAMYCIN SIGNALING AND FORKHEAD-BOX TRANSCRIPTION FACTOR 3A PHOSPHORYLATION ARE INVOLVED IN TESTOSTERONE'S EFFECT ON SEVERE BURN INJURY IN A RAT MODEL. SHOCK 43:85-91(2015).
