FBXL2
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Official Full Name
F-box and leucine-rich repeat protein 2 -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
FBXL2;F-box and leucine-rich repeat protein 2;F-box/LRR-repeat protein 2;FBL2;FBL3;DKFZP564P0622;F box and leucine rich repeat protein 2;F-box protein containing leucine-rich repeats;F-box protein FBL2/FBL3;FBL 2;FBL 3;FBXL 2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Yeast
- HEK293T
- In Vitro Cell Free System
- HEK293
- Mammalian cells
- His
- GST
- His&SUMO
- Myc&DDK
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FBXL2-3779H | Recombinant Human FBXL2 protein, His-tagged | E.coli | Human | His | 341 - 423 aa | |
| FBXL2-10458Z | Recombinant Zebrafish FBXL2 | Mammalian Cell | Zebrafish | His |
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| FBXL2-3898H | Recombinant Human FBXL2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FBXL2-1159H | Recombinant Human FBXL2 Protein (1-423 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-423 aa |
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| FBXL2-2298H | Recombinant Human FBXL2 Protein (1-423 aa), His-tagged | Yeast | Human | His | 1-423 aa |
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| Fbxl2-2962M | Recombinant Mouse Fbxl2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| FBXL2-4964HF | Recombinant Full Length Human FBXL2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 423 amino acids |
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| FBXL2-895H | Recombinant Human FBXL2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| FBXL2-895H-B | Recombinant Human FBXL2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| FBXL2-961HFL | Recombinant Full Length Human FBXL2 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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Involved Pathway
FBXL2 involved in several pathways and played different roles in them. We selected most pathways FBXL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
FBXL2 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL2 itself. We selected most functions FBXL2 had, and list some proteins which have the same functions with FBXL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin protein ligase activity | CUL3,CUL5A,CUL5,FBXL3A,UBXN6,CUL2,FBXL6,FBXL12,FBXL3B,FBXL5 |
Interacting Protein
FBXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL2.
Resources
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References
- Salamon, S; Nowacka-Woszuk, J; et al. A Lack of Association between Polymorphisms of Three Positional Candidate Genes (CLASP2, UBP1, and FBXL2) and Canine Disorder of Sexual Development (78,XX; SRY-Negative). SEXUAL DEVELOPMENT 8:160-165(2014).
- Mallampalli, RK; Coon, TA; et al. Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. JOURNAL OF IMMUNOLOGY 191:5247-5255(2013).
