FBLN1

  • Official Full Name

    fibulin 1

  • Overview

    Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.

  • Synonyms

    FBLN1;fibulin 1;fibulin-1;FBLN;Basement membrane protein 90;BM 90;FBLN1_HUMAN;FIBL 1;FIBL-1;FIBL1;OTTHUMP00000199864;OTTHUMP00000199865;OTTHUMP00000199866;OTTHUMP00000199867;OTTHUMP00000214005

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Wheat Germ
  • Mammalian Cell
  • HEK293T
  • In Vitro Cell Free System
  • Yeast
  • Mamanlian cells
  • GST
  • Myc&DDK
  • Non
  • His
  • HA
  • His&Myc
  • Flag
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
FBLN1-12764H Recombinant Human FBLN1, GST-tagged E.coli Human GST 1-300a.a.
FBLN1-16H Recombinant Human FBLN1 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
FBLN1-28901TH Recombinant Human FBLN1 Wheat Germ Human Non 100 amino acids
FBLN1-28904TH Recombinant Human FBLN1 Wheat Germ Human Non 683 amino acids
FBLN1-3872H Recombinant Human FBLN1 Protein, GST-tagged Wheat Germ Human GST
FBLN1-5740C Recombinant Chicken FBLN1 Mammalian Cell Chicken His
FBLN1-8670Z Recombinant Zebrafish FBLN1 Mammalian Cell Zebrafish His
FBLN1-598HCL Recombinant Human FBLN1 cell lysate Human Non
FBLN1-01H Active Recombinant Human FBLN1 Protein, HA-tagged HEK293 Human HA 30-683 a.a.
Fbln1-1023M Recombinant Mouse Fbln1 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
FBLN1-1463H Recombinant Human FBLN1 Protein, His-tagged E.coli Human His Glu127-Arg241
FBLN1-1464H Recombinant Human FBLN1 Protein, His-tagged E.coli Human His Asp30-Val398+LEHHHHHH
FBLN1-166HF Recombinant Full Length Human FBLN1 Protein In Vitro Cell Free System Human Full L. 683 amino acids
FBLN1-2429H Recombinant Human FBLN1 Protein (30-703 aa), His-Myc-tagged Yeast Human His&Myc 30-703 aa
FBLN1-4880HF Recombinant Full Length Human FBLN1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 683 amino acids
FBLN1-6144H Recombinant Human FBLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
FBLN1-6793HFL Recombinant Full Length Human FBLN1 protein, Flag-tagged Mamanlian cells Human Flag Full L.
FBLN1-723H Recombinant Human FBLN1 Protein, His-tagged E.coli Human His Leu176~Val398
Fbln1-724M Recombinant Mouse Fbln1 Protein, His-tagged E.coli Mouse His Cys399~Arg578
Fbln1-725R Recombinant Rat Fbln1 Protein, His-tagged E.coli Rat His Tyr347~Asn521
Fbln1-726R Recombinant Rat Fbln1 Protein, His/GST-tagged E.coli Rat His&GST Glu127~Arg243

    Involved Pathway

    FBLN1 involved in several pathways and played different roles in them. We selected most pathways FBLN1 participated on our site, such as Elastic fibre formation,Extracellular matrix organization,Molecules associated with elastic fibres, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Extracellular matrix organization ADAMTS3,CRTAP,BMP10,COL8A2,ELANE,MMP24,COL5A3A,MMP11,DDR2,BMP1A
    Elastic fibre formation LOXL4,LOXL1,LOXL3,MFAP2,LTBP4,FURINB,FBLN2,MFAP1B,LOXL2,BMP10
    Molecules associated with elastic fibres MFAP5,FBLN2,EFEMP2,LTBP4,MFAP3,MFAP1B,MFAP2,LTBP2,EFEMP1,LTBP3

    Protein Function

    FBLN1 has several biochemical functions, for example, calcium ion binding,extracellular matrix structural constituent,fibrinogen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN1 itself. We selected most functions FBLN1 had, and list some proteins which have the same functions with FBLN1. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding CYR61,THY1,ADAM15,PTPN2,ADAM17,WISP1,SRC,ICAM3,FERMT3,ADAMTS8
    peptidase activator activity MMP14,CLPX,MMP25,PCOLCE2,PSME4B,PCOLCE,PSME4,CAV1,PINK1,APP
    calcium ion binding CALN1,MASP2,GUCA1D,JAG1A,MYL4,CDH12A,MYL9,CA,LPCAT2,SPARC
    extracellular matrix structural constituent MFAP5,COL27A1A,KAL1,COL2A1A,MGP,ELN,COL4A5,IMPG2,FBN1,TINAGL1
    identical protein binding VIL1,SHARPIN,SMAD4,MRAP2,PDCD6,LCK,G6PD,ALDOA,SMURF2,PIK3AP1
    protein C-terminus binding DBNL,SDCBP2,PPP2CA,PEX16,YWHAQ,STIP1,RAD51,PPP2CB,PRKAA1,NCL
    fibronectin binding CTGF,VEGFA,PLEKHA2,THBS1,CTSL1,ITGA3,CTSS,FSTL3,IGFBP5B,LPA
    fibrinogen binding ITGA2B,MFAP2,THBS1
    protein binding C18orf1,EHD4,USP36,ROPN1,TRAP1,C7orf25,OSTC,MORF4L1,CDH1,CNOT4

    Interacting Protein

    FBLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN1.

    APOA1;SMAD3;YWHAQ;MPG;Tubb4b;CACNA1A;BHLHE40;PLSCR1;FN1;TFAP2A;SKIL;TDGF1;ATN1;SMAD4;GFI1B;EDC4

    Resources

    References

    • Perez-Rico, C; Pascual, G; et al. Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:6309-6318(2014).
    • Long, KB; Artlett, CM; et al. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. MATRIX BIOLOGY 38:91-100(2014).

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