FASTK
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Official Full Name
Fas-activated serine/threonine kinase -
Overview
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. -
Synonyms
FASTK;Fas-activated serine/threonine kinase;FAST;Fas activated serine threonine kinase;Fas activated serine threonine kinase isoform 1;Fas activated serine threonine kinase isoform 4;FAST kinase;FLJ13079
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- Myc&DDK
Involved Pathway
FASTK involved in several pathways and played different roles in them. We selected most pathways FASTK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FASTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FASTK has several biochemical functions, for example, ATP binding,Fas-activated serine/threonine kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FASTK itself. We selected most functions FASTK had, and list some proteins which have the same functions with FASTK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MARCH5,ERLEC1,ZNF404,SPINK7,C6orf226,INTS12,PGBD1,PYCARD,WARS,SNAI1 |
| ATP binding | CFTR,KIF25,MAP2K5,TTL,INO80,PPP2R4,LONP1,BMPR1BB,PKZ,RPS6KB2 |
| protein serine/threonine kinase activity | RPS6KA3A,PAK1,PRKCA,DYRK1B,PAK2B,PAK3,CAMK2B1,IRAK4,PRKCE,MAST4 |
Interacting Protein
FASTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASTK here. Most of them are supplied by our site. Hope this information will be useful for your research of FASTK.
WIPF1;TNKS2;HSP90AB1;CRK
Resources
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References
- Jourdain, AA; Koppen, M; et al. A Mitochondria-Specific Isoform of FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function. CELL REPORTS 10:1110-1121(2015).
- Zhi, F; Zhou, GX; et al. miR-106a-5p Inhibits the Proliferation and Migration of Astrocytoma Cells and Promotes Apoptosis by Targeting FASTK. PLOS ONE 8:-(2013).
