FARS2
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Official Full Name
phenylalanyl-tRNA synthetase 2, mitochondrial -
Overview
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm. -
Synonyms
FARS2;phenylalanyl-tRNA synthetase 2, mitochondrial;FARS1, phenylalanine tRNA synthetase 1 (mitochondrial);phenylalanyl-tRNA synthetase, mitochondrial;dJ236A3.1;phenylalanine tRNA ligase 2;mitochondrial;dJ236A3.1 (phenylalanine tRNA synthetase);dJ520B18.2 (FARS1 (phenylalanine tRNA synthetase));FARS1;HSPC320;Phenylalanine translase;Phenylalanine tRNA ligase 2, mitochondrial;Phenylalanine tRNA ligase;Phenylalanine tRNA synthetase 1 (mitochondrial);Phenylalanine tRNA synthetase 2 (mitochondrial);Phenylalanine--tRNA ligase;Phenylalanyl tRNA synthetase 2;PheRS;SYFM_HUMAN;OTTHUMP00000015986;dJ236A3.1 (phenylalanine-tRNA synthetase);phenylalanine-tRNA synthetase 1 (mitochondrial);phenylal;dJ520B18.2
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FARS2 involved in several pathways and played different roles in them. We selected most pathways FARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis,Gene Expression,Mitochondrial tRNA aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA Aminoacylation | DARS,EARS2,AIMP2,AARS,KARS,MADD,AIMP1,WARS2,EEF1E1,FARSB |
| Aminoacyl-tRNA biosynthesis | VARS,TARS2,QRSL1,CARS,FARSA,AARS,GARS,GATB,LARS,RARS2 |
| Gene Expression | GATAD2AB,EIF2S3,ZNF225,MADD,EED,CCAR1,HBXIP,ZNF3,MTA3,AIMP2 |
| Mitochondrial tRNA aminoacylation | KARS,EARS2,WARS2 |
Protein Function
FARS2 has several biochemical functions, for example, ATP binding,magnesium ion binding,phenylalanine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FARS2 itself. We selected most functions FARS2 had, and list some proteins which have the same functions with FARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phenylalanine-tRNA ligase activity | FDXACB1,FARSB,FARSA |
| magnesium ion binding | NIM1K,STK38,ENO1,PRPS1,PGM3,NLK,HACL1,NEK6,ATP8B1,PCK1 |
| protein binding | MAP3K9,RNF216,AGFG1,SFPI1,SPDL1,COP1,UGGT1,ATP6V0A2,LRGUK,CBX4 |
| tRNA binding | TRMT1L,RPL35A,THG1L,XPOT,NSUN2,EIF2A,AARS2,RARS,MADD,CTU2 |
| ATP binding | FGFR1B,CCT7,PKM,PRKCQ,CHD6,DAK,CENPE,ABCC11,CDK13,ACSL4 |
Interacting Protein
FARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FARS2.
KRT13;TADA2A;STX11;RCBTB2;TRIM27;KRTAP10-5
Resources
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References
- Klipcan, L; Moor, N; et al. Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State. JOURNAL OF MOLECULAR BIOLOGY 415:527-537(2012).
- Finarov, I; Moor, N; et al. Structure of Human Cytosolic Phenylalanyl-tRNA Synthetase: Evidence for Kingdom-Specific Design of the Active Sites and tRNA Binding Patterns. STRUCTURE 18:343-353(2010).
