FAHD1
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Official Full Name
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -
Overview
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. -
Synonyms
TNKS2;tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2;tankyrase-2;PARP 5b;PARP 5c;PARP5B;PARP5C;pART6;TANK2;TNKL;TNKS-2;tankyrase 2;tankyrase II;tankyrase-like protein;tankyrase-related protein;poly [ADP-ribose] polymerase 5B;TRF1-interacting ankyrin-related ADP-ribose polymerase 2;PARP-5b;PARP-5c
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
FAHD1 involved in several pathways and played different roles in them. We selected most pathways FAHD1 participated on our site, such as Tyrosine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAHD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | OXSR1,ENPP1,NDUFA1,MTHFR,GOT2B,NDST4,MTHFD1L,PIK3C3,EBP,LASS1 |
| Tyrosine metabolism | AOX3,HGD,ADH1,FAH,DCT,ALDH3A1,TPO,AOX4,TAT,AOC2 |
Protein Function
FAHD1 has several biochemical functions, for example, acetylpyruvate hydrolase activity,acylpyruvate hydrolase activity,fumarylpyruvate hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FAHD1 itself. We selected most functions FAHD1 had, and list some proteins which have the same functions with FAHD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | POMT1,CFI,SAP30,MBNL2,TOE1,CNOT4B,FOXP2,MAT2AA,PRDM12,PC |
| oxaloacetate decarboxylase activity | ME1,ME3,ME2 |
Interacting Protein
FAHD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAHD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FAHD1.
PPAP2A;EXOSC4;MME
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