F5
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Official Full Name
coagulation factor V (proaccelerin, labile factor) -
Overview
Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis. Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation. -
Synonyms
F5;FVL;PCCF;coagulation factor V;factor V Leiden;OTTHUMP00000032547;OTTHUMP00000032548;proaccelerin, labile factor;activated protein c cofactor;coagulation factor V jinjiang A2 domain;coagulation factor V (proaccelerin, labile factor)
Recombinant Proteins
- Bovine
- Zebrafish
- Human
- Mouse
- Cattle
- Pig
- Snake
- Rat
- Plasma
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Snake Venom
- Human plasma
- Non
- His
- GST
- His&GST
- His&T7
- His&SUMO
- His&Fc&Avi
Involved Pathway
F5 involved in several pathways and played different roles in them. We selected most pathways F5 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | PLG,PLAU,CD59A,THBD,CR1,F7,VWF,C3,C8B,SERPINA5 |
Protein Function
F5 has several biochemical functions, for example, copper ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by F5 itself. We selected most functions F5 had, and list some proteins which have the same functions with F5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BLOC1S6,SLC9A3,ECE2,CORO6,ZNF295,TBC1D17,MYOZ1,ARPC2,PTPN4,SDCBP2 |
| copper ion binding | HEPHL1A,LOX,P2RX4,SCO2,LOXL3A,TRP53,PARK7,MT3,SERPINB1A,POLR1B |
Interacting Protein
F5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F5 here. Most of them are supplied by our site. Hope this information will be useful for your research of F5.
BJLF1
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References
- Calliari, CM; de Souza, EL; et al. Characterisation and microstructure of reduced-fat chicken patties made with a novel polymer from Agrobacterium radiobacter k84. FOOD CHEMISTRY 173:1150-1157(2015).
- Nuzzo, F; Bulato, C; et al. Characterization of an apparently synonymous F5 mutation causing aberrant splicing and factor V deficiency. HAEMOPHILIA 21:241-248(2015).
