EXOSC1
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Official Full Name
exosome component 1 -
Overview
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. -
Synonyms
EXOSC1;exosome component 1;exosome complex component CSL4;CGI 108;CSL4;CSL4 exosomal core protein homolog (yeast);Csl4p;hCsl4p;p13;SKI4;Ski4p;RP11-452K12.9;3-5 exoribonuclease CSL4 homolog;exosomal core protein CSL4;CSL4 exosomal core protein homolog;homolog of yeast exosomal core protein CSL4;CGI-108
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
EXOSC1 involved in several pathways and played different roles in them. We selected most pathways EXOSC1 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOSC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA degradation | SKIV2L2,LSM8,SKIV2L,BTG3,PABPC1,BTG4,CNOT4,HSPD1,TTC37,EDC4 |
Protein Function
EXOSC1 has several biochemical functions, for example, RNA binding,NOT exoribonuclease activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOSC1 itself. We selected most functions EXOSC1 had, and list some proteins which have the same functions with EXOSC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT exoribonuclease activity | EXOSC5,EXOSC8,EXOSC4,EXOSC7,EXOSC2,EXOSC3 |
| RNA binding | DNMT1,RNASET2,RPL30,ADAD1,XPO5,CELF6,NOVA2,SRRM4,ETF1,RPL19 |
| protein binding | HADHA,SRGAP3,TGFBI,CCDC24,KIF2C,CSF2RB,SPAG9,AICDA,AP2B1,PYGO2 |
Interacting Protein
EXOSC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOSC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOSC1.
EXOSC5;EXOSC7
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