ERCC1

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

  • Overview

    The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.

  • Synonyms

    ERCC1;excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence);DNA excision repair protein ERCC-1;RAD10;UV20;COFS4

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • GST
  • Non
  • His
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
ERCC1-12521H Recombinant Human ERCC1, GST-tagged E.coli Human GST 1-323a.a.
ERCC1-2396H Recombinant Human ERCC1 E.coli Human Non Full L. 448-568 a.a.
ERCC1-28691TH Recombinant Human ERCC1 E.coli Human Non Full L. 1-297 a.a.
ERCC1-3455H Recombinant Human ERCC1 Protein, GST-tagged Wheat Germ Human GST
ERCC1-5967Z Recombinant Zebrafish ERCC1 Mammalian Cell Zebrafish His
ERCC1-6778H Recombinant Human ERCC1, His-tagged E.coli Human His
ERCC1-6567HCL Recombinant Human ERCC1 293 Cell Lysate HEK293 Human Non
ERCC1-6568HCL Recombinant Human ERCC1 293 Cell Lysate HEK293 Human Non
ERCC1-2237H Recombinant Human ERCC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
ERCC1-2820H Recombinant Human ERCC1 Protein (Met1-Pro297), N-His tagged E.coli Human His Met1-Pro297
ERCC1-2821H Recombinant Human ERCC1 Protein (Met1-Pro323), His tagged E.coli Human His Met1-Pro323
ERCC1-4529HF Recombinant Full Length Human ERCC1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 323 amino acids
ERCC1-4665H Recombinant Human ERCC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Ercc1-972M Recombinant Mouse Ercc1 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    ERCC1 involved in several pathways and played different roles in them. We selected most pathways ERCC1 participated on our site, such as Nucleotide excision repair,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nucleotide Excision Repair RAD23B,KIAA1530,ERCC5,CHD1L,RAD23AB,CUL4B,COPS3,MNAT1,YY1,POLE2
    Fanconi Anemia Pathway RMI2,POLI,FANCI,STRA13,RMI1,FANCD2,RPA1,REV1,FAN1,ZBTB32

    Protein Function

    ERCC1 has several biochemical functions, for example, TFIID-class transcription factor binding,damaged DNA binding,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC1 itself. We selected most functions ERCC1 had, and list some proteins which have the same functions with ERCC1. You can find most of the proteins on our site.

    Function Related Protein
    TFIID-class transcription factor binding FBL,NOP58,ZNHIT6,ERCC4
    contributes_to structure-specific DNA binding ERCC4
    protein C-terminus binding MSH2,SP1,NCF2,MKI67,YWHAQ,FBLN1,HESX1,PRKAA1,MRE11A,PDZD3
    protein binding XIAP,BMP1A,HNRPLL,LRDD,ZRANB1,CDK13,CDH23,CLK3,IL36RN,BCL10
    damaged DNA binding ERCC4,TP53BP1,NEIL2,PNKP,POLH,NEIL3,RUVBL2,POLB,ERCC3,APTX
    single-stranded DNA binding CRY2,RAD51L1,PMS1,TREX1,RAD51L3,PURA,BLM,HNRNPDL,PEO1,TDP2B
    protein domain specific binding VAPA,WNT5A,E2F4,NEFL,FOXH1,DRD3,TFDP1,YWHABL,PICK1,RAP2B
    contributes_to single-stranded DNA endodeoxyribonuclease activity RAD50

    Interacting Protein

    ERCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC1.

    UBL7;SLX4;EGFR

    Resources

    Research Area

    DNA Damage and Repair
    Bladder Cancer Biomarkers
    Head and Neck Cancer Biomarkers
    Nucleotide Excision Repair/Transcription Coupled Repair

    References

    • Kuhlmann, JD; Wimberger, P; et al. ERCC1-Positive Circulating Tumor Cells in the Blood of Ovarian Cancer Patients as a Predictive Biomarker for Platinum Resistance. CLINICAL CHEMISTRY 60:1282-1289(2014).
    • Dudas, J; Schartinger, VH; et al. Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer. TUMOR BIOLOGY 35:7807-7819(2014).

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