EPAS1
-
Official Full Name
endothelial PAS domain protein 1 -
Overview
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. -
Synonyms
EPAS1;endothelial PAS domain protein 1;endothelial PAS domain-containing protein 1;mHLF;EPAS-1;HIF2-alpha;HIF-2-alpha;Hif like protein;HIF-related factor;HIF1alpha-like factor;HIF1 alpha-like factor;HIF-1-alpha-like factor;HLF (HIF1alpha-like
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Baculovirus-Insect cells
- In Vitro Cell Free System
- GST
- His&S
- His
- Non
- His&Fc&Avi
Involved Pathway
EPAS1 involved in several pathways and played different roles in them. We selected most pathways EPAS1 participated on our site, such as Pathways in cancer,Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | PIK3R5,PTPN11,VHL,CDC42,EGLN2,ETS1,PDGFB,RAF1,HIF1A,PAK1 |
| Pathways in cancer | GSK3B,LAMB3,SUFU,BCL2,GNAI2,IGF1,PTK2,CASP8,ITGA6,ITGA2 |
Protein Function
EPAS1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,histone acetyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPAS1 itself. We selected most functions EPAS1 had, and list some proteins which have the same functions with EPAS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | TRIB1,E2F4,TFDP1B,MECP2,TLE1,MYOD1,HDAC2,ENPP2,NFKB1,SIRT1 |
| DNA binding | MYC,ZBTB18,MYCN,ESRRA,TOPBP1,LBX1B,NKX1.2LA,ZNF445,PEG10,ZNF559 |
| contributes_to sequence-specific DNA binding | NEUROD1,TCF3,HDAC4,HIF1A,SMAD4,PPARG,FIGLA,ARNT,TRIM28,HNRNPAB |
| protein binding | PCBD1,AIP,FGF10,MSX2,SENP3,POR,BCL11B,PLK1,VPS8,FCGR2C |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | ELF2A,JUNBA,SOX8B,SPDEF,PEG3,ZNF131,TFDP1,FOXM1,FLI1B,JUNBB |
| protein heterodimerization activity | IL12A,BCL2A1A,PEF1,NOTCH1,ERBB3,IKZF1,MYOD1,HIST2H2L,ARNT,DMBX1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PLAG1,ONECUT3,ETV1,ZNF750,MAFA,NKX2-5,IRF1,TCF4,MITF,CREB3 |
| histone acetyltransferase binding | EID1,EGR1,MTF1,TRP53,PCNA,FOXP3,TRIP4,TP53,TRIM68,ZBTB7A |
Interacting Protein
EPAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPAS1.
EIF3E;SMAD3;USP8;BBS4;EGLN1;PDK1;PIAS2
Resources
Research Area
Transcription Regulators in VSMCTranscription Factors in the Akt Pathway
Cancer Stem Cell Transcription Factors
Intracellular Signaling Molecules in Angiogenesis
Glioma/Medulloblastoma Cancer Stem Cell Markers
Melanoma Biomarkers
Related Services
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References
