ENPP2
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Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 2 -
Overview
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5 end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ENPP2;ectonucleotide pyrophosphatase/phosphodiesterase 2;PDNP2;ectonucleotide pyrophosphatase/phosphodiesterase family member 2;ATX;autotaxin;PD IALPHA;ATX X;ATX-X;Autotaxin t;E NPP 2;E-NPP 2;ENPP2_HUMAN;Extracellular lysophospholipase D;FLJ26803;LysoPLD;NPP2;PD-IALPHA;Phosphodiesterase I alpha;Phosphodiesterase I/nucleotide pyrophosphatase 2;Plasma lysophospholipase D;autotaxin-t;OTTHUMP00000228158;OTTHUMP00000228159;OTTHUMP00000228161;OTTHUMP00000228162;phosphodiesterase I/nucleotide py
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Zebrafish
- Rat
- Chicken
- HEK293
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- Human Cell
- Insect Cells
- Insect cell
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
ENPP2 involved in several pathways and played different roles in them. We selected most pathways ENPP2 participated on our site, such as Ether lipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENPP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ether lipid metabolism | PLA2G4A,PLB1,LPCAT4,PLA2G4F,PLA2G2F,PLA2G2E,ENPP6,PPAP2B,UGT8A,PAFAH1B1 |
Protein Function
ENPP2 has several biochemical functions, for example, alkylglycerophosphoethanolamine phosphodiesterase activity,calcium ion binding,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENPP2 itself. We selected most functions ENPP2 had, and list some proteins which have the same functions with ENPP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide diphosphatase activity | ENPP1 |
| nucleic acid binding | JAZF1,ALYREF,ZFPM2,DHX36,GFI1AB,SF3B6,DDX39,ZFP422,RNASEL3,ZFP821 |
| hydrolase activity | PRSS48,PLAUA,CTSBA,LIPK,ABHD17B,GM5136,IDI2,OTUD5A,PA2G4B,CTSLL |
| scavenger receptor activity | SCARF2,LOXL3A,CD163L1,TMPRSS4B,LOXL2,VTNA,MSR1,PRG4B,ACKR4,SCARA3 |
| transcription factor binding | HOXA7,NCOR2,FHL2,ARRB1,PARP1,KCTD1,PURA,TLE1,BRD7,HES4 |
| polysaccharide binding | SUSD2,PRG4,TINAGL1,TINAG,CD209B,CLEC4G,VTN,VTNA,MBL1,PRG4A |
| phosphodiesterase I activity | FAN1,ENPP1,APEX1 |
| zinc ion binding | RNF141,MSRB1,OAS2,PRKCBB,NRD1B,ZCCHC13,ZFAND4,TRIM24,GCH2,PTER |
| calcium ion binding | MFGE8B,SRR,PCDH1GC6,SYT6,PLCH2,RET,CD97,MMP17,MAN1A1,CANT1A |
Interacting Protein
ENPP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENPP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENPP2.
Dlg4;HSPB1
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