EN2
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Official Full Name
engrailed homeobox 2 -
Overview
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the engrailed (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. -
Synonyms
EN2;engrailed homeobox 2;homeobox protein engrailed-2;AUTS 1;AUTS1;EN 2;Engrailed 2;Engrailed homeo box 2;Engrailed homolog 2;Engrailed2;Homeobox protein engrailed 2;Homeobox protein engrailed2;Hu En 2;HuEn2;MabEn;hu-En-2;engrailed-2;OTTHUMP00000199895;homeobox protein en-2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
EN2 involved in several pathways and played different roles in them. We selected most pathways EN2 participated on our site, such as Dopminergic Neurogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with EN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopminergic Neurogenesis | EN1 |
Protein Function
EN2 has several biochemical functions, for example, DNA binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EN2 itself. We selected most functions EN2 had, and list some proteins which have the same functions with EN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP710,THAP5,SSH1,LYL1,TTC4,NFE2L2B,HIST1H4F,MCM6L,ZNF512,HOXC12A |
| sequence-specific DNA binding | HOXB2,FOXQ1,MAFBB,HOXD10A,GRHL3,ELF2,FOXP2,HOXB6B,SOX13,ERG |
Interacting Protein
EN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EN2.
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References
- Lee, S; Jo, H; et al. Ultrasensitive electrochemical detection of engrailed-2 based on homeodomain-specific DNA probe recognition for the diagnosis of prostate cancer. BIOSENSORS & BIOELECTRONICS 66:32-38(2015).
- de Mey, C; Gatchev, E; et al. Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53:247-255(2015).
