EIF4E
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Official Full Name
eukaryotic translation initiation factor 4E -
Overview
Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. -
Synonyms
EIF4E;eukaryotic translation initiation factor 4E;CBP;EIF4F;EIF4E1;EIF4EL1;MGC111573;eIF-4E;OTTHUMP00000219701;OTTHUMP00000219702;OTTHUMP00000219703;OTTHUMP00000219704;OTTHUMP00000219705;eIF-4F 25 kDa subunit;mRNA cap-binding protein;eukaryotic translation initiation factor 4E-like 1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
EIF4E involved in several pathways and played different roles in them. We selected most pathways EIF4E participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Alpha6-Beta4 Integrin Signaling Pathway,Antiviral mechanism by IFN-stimulated genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4B,EIF2S1,EIF4G1,EIF1AXA,EIF4A1,EIF4EB,EIF4EBP1,EIF3K,EIF2S1A,EIF4A2 |
| Antiviral mechanism by IFN-stimulated genes | USP18,EIF4E3,IFIT11,NUPL2,DPF1,JAK1,MX2,ARIH1L,IFIT10,EIF4A2 |
| Alpha6-Beta4 Integrin Signaling Pathway | YWHAQ,DST,CDKN1A,NTN1A,DSP,EIF4EB,CLCA1,EIF4EBP1,CD151L,SMAD3B |
| Deadenylation of mRNA | TNKS1BP1,EIF4EB,EIF4A1,D1BWG0212E,PAIP1,C2orf29,EIF4G1,EIF4A2,EIF4B |
| BDNF signaling pathway | GNB2L1,CDH2,IGF2BP1,EEF2,CFL1,CSNK2A1,CDK5,EIF2S1,SIRPA,CDKL5 |
| Cap-dependent Translation Initiation | EIF2S1,EIF4G1,EIF4EB,EIF2S1A,EIF1AXA,FAUB,EIF2S3,EIF4A2,EIF5,EIF4B |
| Cytokine Signaling in Immune system | IFI6,IRF2,KBTBD7,KLB,FRS2A,HLA-DQB2,TNIP2,SAMHD1,TRIM6,OASL |
| Deadenylation-dependent mRNA decay | DCP2,EIF4EB,TNKS1BP1,NT5C3B,C2orf29,EXOSC8,EIF4A1,PAIP1,EIF4A2,LSM6 |
Protein Function
EIF4E has several biochemical functions, for example, RNA cap binding,enzyme binding,eukaryotic initiation factor 4G binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4E itself. We selected most functions EIF4E had, and list some proteins which have the same functions with EIF4E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | METTL17,H3F3C,DULLARD,POLG2,CLIP1,CDAN1,ADAMTSL5,PCNA,EIF4A1,DPYSL2 |
| enzyme binding | CPSF1,CBX3,PCBP2,MSH2,EIF2AK3,PARP4,HDAC3,TOP2B,Txn1,TNKS2 |
| translation initiation factor activity | GTPBP2,EIF4E2RS1,EIF2S3,EIF1B,EIF4EA,EIF1,COPS5,EIF3S6IP,DENR,EIF3E |
| RNA cap binding | EIF4A1,NCBP2,LARP1,EIF4G3,NCBP1,SNUPN,EIF4E2 |
| poly(A) RNA binding | G3BP1,AHNAK,POU5F1,TRIP6,RPS4Y2,CAPRIN1,THUMPD1,RPL18A,HIST1H4K,HIST1H4B |
| repressing transcription factor binding | NFYB,PRDM5,HDAC4,DDX20,MYC,MAGEA2B,CBX5,TCF3,HMGB1,SRI |
Interacting Protein
EIF4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4E here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4E.
EIF4EBP1;EIF4ENIF1
EIF4E Related Signal Pathway
Resources
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References
- Moodley, V; Naidoo, R; et al. Screening of pepper (Capsicum annuum L.) lines for resistance to an isolate of Potato virus Y (PVY) occurring in KwaZulu-Natal (KZN), Republic of South Africa. CROP PROTECTION 68:36-40(2015).
- Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
Reviews
Q&As
EIF4E-2775H is a full-length protein that contains all binding sites; we highly recommend you try this protein.